178876-86-3

Basic information

• Product Name: Methyl 5-broMo-6-oxo-1,6-dihydropyridine-2-carboxylate
• Synonyms: methyl 5-bromo-1,6-dihydro-6-oxopyridine-2-carboxylate;methyl5-bromo-6-hydroxypicolinate;Methyl 5-broMo-6-oxo-1,6-dihydropyridine-2-carboxylate;5-Bromo-1,6-dihydro-6-oxo-2-pyridinecarboxylic acid methyl ester
• CAS NO: 178876-86-3
• Molecular Formula: C₇H₆BrNO₃
• Molecular Weight: 232.03144
• Mol File: 178876-86-3.mol

Chemical Properties

• Boiling Point: 374.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.737±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 7.34±0.10(Predicted)
• CAS DataBase Reference: Methyl 5-broMo-6-oxo-1,6-dihydropyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-broMo-6-oxo-1,6-dihydropyridine-2-carboxylate(178876-86-3)
• EPA Substance Registry System: Methyl 5-broMo-6-oxo-1,6-dihydropyridine-2-carboxylate(178876-86-3)

Safety Data

• Hazardous Substances Data: 178876-86-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
Methyl 5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylate is used as a research compound for the development of new pharmaceuticals. Its unique structure and properties make it a valuable component in the synthesis of pyridine derivatives, which have potential therapeutic applications.
Used in Synthesis of Pyridine Derivatives:
In the field of organic chemistry, methyl 5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylate is used as a key intermediate in the synthesis of pyridine derivatives. These derivatives are known for their diverse biological activities and potential use in drug development, making methyl 5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylate an essential component in the creation of novel therapeutic agents.
Used in Medicinal Chemistry:
Methyl 5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylate is employed as a building block in medicinal chemistry for the design and synthesis of new drugs. Its unique structure allows for the development of compounds with specific biological activities, contributing to the advancement of pharmaceutical research.
Used in Biological Research:
methyl 5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylate is also used in biological research to study the interactions of pyridine derivatives with biological systems. Its involvement in the synthesis of pyridine derivatives with potential biological activities makes it a valuable tool for understanding the mechanisms of action and potential applications of these compounds in various biological processes.

Upstream product

• 26893-72-1 6-acetamido-picolinic acid 
• 36052-26-3 methyl 6-aminopyridine-2-carboxylate 
• 5327-33-3 2-acetylamino-6-methylpyridine 
• 1824-81-3 2-Amino-6-methylpyridine 
• 178876-82-9 6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester 

Relevant articles and documents

Total synthesis of dimethyl sulfomycinamate

Dimethyl sulfomycinamate (1), a methanolysis product from the natural antibiotic sulfomycin I, is synthesized in 11 steps. The chemistry of various pyridine, thiazole, and oxazole heterocycles and their coupling reactions under palladium catalysis are examined. The key transformations in the synthesis are the selective palladium-catalyzed coupling reactions on doubly activated pyridine 62 and the condensation reaction between bromo ketone 69 and amide 28 to form the oxazole moiety 76. The first preparation of oxazole triflates is described, as are some of their chemical properties.