17888-08-3Relevant academic research and scientific papers
One-Pot Reductive Alkylation of 2,4-Dihydroxy Quinolines and Pyridines
Chheda, Pratik R.,Kummer, David A.,Nishimura, Rachel T.,McClure, Kelly J.,Venkatesan, Hariharan
, p. 7148 - 7162 (2021)
A one-pot, Hantzsch ester-mediated Knoevenagel condensation-reduction reaction has been developed for alkylation of a wide range of substituted 2,4-quinoline diols and 2,4-pyridine diols with aldehydes. The process is operationally simple to perform, scalable, and provides highly useful C-3 alkylated quinoline and pyridine diols in yields of 58-92%. The alkylation products can be converted to 2,4-dihaloquinoline and pyridine substrates for further functionalization.
