178899-97-3

Upstream product

• 5454-83-1 5-bromovaleric acid methyl ester 
• 56613-80-0 D-2-phenylglycinol 
• 155796-94-4 (αR)-N-(2-hydroxy-1-phenylethyl)piperidine-2-one 

Downstream Products

• 178757-03-4 (αR,3R)-N-(2-hydroxy-1-phenylethyl)-3-phthalimidopiperidin-2-one 
• 1342814-89-4 (1'R,3R)-1-(2-hydroxy-1-phenylethyl)-3-(3-methoxyphenyl)piperidin-2-one 
• 1342814-91-8 (1'R,3R)-1-(2-hydroxy-1-phenylethyl)-3-(2-tolyl)piperidin-2-one 
• 1342814-88-3 (1'R,3R)-1-(2-hydroxy-1-phenylethyl)-3-(2-methoxyphenyl)piperidin-2-one 
• 430461-53-3 (3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-phenylpiperidine 
• 1342814-86-1 (1'R,3R)-1-(2-hydroxy-1-phenylethyl)-3-phenylpiperidin-2-one 
• 1342814-87-2 (3S,3'S)-1,1'-bis((R)-2-hydroxy-1-phenylethyl)-[3,3'-bipiperidine]-2,2'-dione 
• 178757-02-3 (αR,3R)-3-azido-N-(2-hydroxy-1-phenylethyl)piperidin-2-one 

Relevant academic research and scientific papers

Asymmetric synthesis. XXXIX. Synthesis of 3-substituted piperidin-2-ones from chiral non-racemic lactams

A series of 3-substituted piperidines in enantiomerically pore form has been synthesized from lactam 1 via the bromo derivative 2i. t-Butyl acetate and 5-methylpyridine derivatives 2g and 2h were obtained optically pure by direct alkylation of 1 with corresponding halides. Azido, amino or benzyloxy products were obtained by diastereoselective substitution of 21.

Conformationally restricted analogues of methionine: Synthesis of chiral 3-amino-5-methylthio-2-piperidones

(αR, 3RS, 5S)-3-Amino-N-(2-hydroxy-1-phenylethyl)-5-methylthio-2- piperidones 1 have been synthesized from enamide 2 by subsequent free radical addition of methanothiol on position 5 and amination of 3-position.