430461-53-3

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 178899-97-3 (1'R,3S)-3-bromo-1-(2-hydroxy-1-phenylethyl)piperidin-2-one 
• 343947-52-4 methyl 5-oxo-4-phenylpentanoate 
• 122-78-1 phenylacetaldehyde 
• 56613-80-0 D-2-phenylglycinol 
• 332-15-0 1-(2-phenylethynyl)piperidine 
• 430461-23-7 (3R,8R,8aR)-3,8-diphenyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 

Downstream Products

• 430461-56-6 (R)-3-phenyl piperidine 

Relevant academic research and scientific papers

Diastereoselective arylation of enantiopure 3-bromopiperidin-2-one derived from (R)-(-)-2-phenylglycinol with organocuprate reagents

The diastereoselective substitution of 3-bromolactam derived from (R)-(-)-2-phenylglycinol with a variety of arylcuprate reagents is presented. The stereochemical outcome of the substitution reaction is discussed. The method provides an efficient and stra

Dynamic kinetic resolution of racemic γ-aryl-δ-oxoesters. Enantioselective synthesis of 3-arylpiperidines

Cyclodehydration of racemic γ-aryl-δ-oxoesters with (R)- or (S)-phenylglycinol stereoselectively affords bicyclic δ-lactams, in a process that involves a dynamic kinetic resolution. Subsequent reduction of these lactams leads to enantiopure 3-arylpiperidines. Starting from racemic aldehyde esters, this short sequence has been applied to the synthesis of (R)-3-phenylpiperidine and the antipsychotic drug (-)-3-PPP (an (S)-3-arylpiperidine), whereas starting from racemic ketone esters enantiopure cis-2-alkyl-3-arylpiperidines are prepared.