178949-98-9

Upstream product

• 111-87-5 octanol 
• 63-91-2 L-phenylalanine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 157254-30-3 (S)-octyl 2-(tert-butoxycarbonylamino)-3-phenylpropanoate 

Downstream Products

• 1268166-97-7 N',N''-dioctyl-N-[(S)-(benzyl)(octyloxycarbonyl)methyl]benzene-1,3,5-tricarboxamide 
• 1052738-18-7 C₃₃H₄₆N₂O₇ 
• 1053618-32-8 C₂₈H₃₈N₂O₅ 
• 1052738-20-1 C₄₁H₆₀N₈O₁₁ 
• 1312439-35-2 C₃₄H₅₅N₇O₉ 
• 1052737-99-1 C₂₉H₄₇N₇O₇ 
• 1594058-49-7 C₁₇H₂₇NO₂*CHF₃O₃S 

Relevant academic research and scientific papers

New amino acid-based anionic surfactants and their use as enantiodiscriminating lyotropic liquid crystalline NMR solvents

New amino acid-based anionic surfactants have been synthesized and their use as chiral oriented NMR solvents studied. A series of sulfonated amphiphilic L-Phe or L-Ala derivatives with pentyl to tetradecyl tails were prepared by reacting the corresponding

Peptidomimetic analogues of an Arg-Trp-x-x-Trp motif responsible for interaction of translocase MraY with bacteriophage ?X174 lysis protein E

Translocase MraY is the target for bacteriophage ?X174 lysis protein E, which interacts via a protein–protein interaction mediated by Phe-288 and Glu-287 of E. coli MraY, and an Arg-Trp-x-x-Trp motif on protein E, also found in several cationic antimicrob

COMPOUNDS USEFUL IN HIV THERAPY

The invention relates to compounds of Formula (I), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.

Synthesis, self-assembly, bacterial and fungal toxicity, and preliminary biodegradation studies of a series of l-phenylalanine-derived surface-active ionic liquids

We report for the first time a comprehensive study on the synthesis (supported by green chemistry metrics), aggregation properties, bacterial/fungal toxicities and preliminary data on biodegradation of a series of 24 l-phenylalanine derived surface-active ionic liquids (SAILs). The various cationic headgroups included pyridinium, imidazolium, and cholinium groups and enabled a comprehensive analysis of the effect of the alkyl ester chain (from C2 to C16) on the synthesis, toxicity, biodegradability, and surfactant properties of the novel SAILs. The evaluation of the SAILs revealed that a wide variety of properties were strictly dependent on the side chain length, including their bacterial and fungal toxicities (from low toxicity to high toxicity), and aggregation properties. Addition of the l-phenylalanine moiety which connects the lipophilic side chain to the cationic head group results in the phenyl group essentially contributing to the self-assembling properties. The interplay of dispersion interactions of the phenyl ring and the side chain hydrophobicity allows us to rank the novel SAILs (thus identifying the remarkable ones) as compared to other surfactants. The CMC values for the SAILs reported in this study are significantly (up to 10 times) lower than those reported for conventional surfactants with the same length of the side chain. Adsorption and micellization are among the factors affecting the toxicity of the studied SAILs. Preliminary biodegradation studies have shown that no clear trend was observed when comparing the closed bottle test results of the SAIL C2 and C10 derivatives. Medium chain length (C6 to C8) pyridinium SAILs have been recommended as the most prospective green alternatives for conventional cationic surfactants. These findings can contribute to designing new efficient amphiphiles with optimized antimicrobial activities and to employ them as potential environmentally benign mineralisable surfactants.

Self-assembly of chiral propeller-like supermolecules with unusual "sergeants-and-soldiers" and "majority-rules" effects

Chiral amplification is an interesting phenomenon in supramolecular chemistry mainly observed in complicated systems in which cooperative effect dominate. Herein, chiral, supramolecular, propeller-like architectures have been constructed through coassembl

C3-Symmetric, amino acid based organogelators and thickeners: a systematic study of structure-property relations

A class of C3-symmetric amino acid based organogelators and thickeners featuring a rigid core have been developed. Structural variation yielded a number of compounds, the aggregation behaviour and resulting aggregates and gels of which were studied by FTIR spectroscopy, dropping ball measurements, differential scanning calorimetry and transmission electron microscopy. These studies showed that the nature of the core unit, the type of hydrogen-bonding units and the applied amino acids have a strong influence on the interactions, resulting in large differences in aggregation properties, thermal stability and morphology between the various compounds. The results provide a basis for a better understanding of the relation between aggregate/gel properties and molecular structure. The structural variation available for these compounds allows fine-tuning of the gelators with respect to aggregation behaviour and gel properties.

Gelling agents

The invention relates to a novel class of gelling agents, to a process of preparing said agents, to the use of said agents to prepare gels, and to the gels thus obtained. A gelling agent or thickener according to the invention comprises a rigid core which is functionalized with three amino acid ester or amide groups by means of an amide or urea linkage. It may be used to gelate or thicken numerous solvents.