178963-27-4Relevant academic research and scientific papers
β-Lactamase inhibition profile of new amidine-substituted diazabicyclooctanes
Iqbal, Zafar,Zhai, Lijuan,Gao, Yuanyu,Tang, Dong,Ma, Xueqin,Ji, Jinbo,Sun, Jian,Ji, Jingwen,Liu, Yuanbai,Jiang, Rui,Mu, Yangxiu,He, Lili,Yang, Haikang,Yang, Zhixiang
supporting information, p. 711 - 718 (2021/04/09)
The diazabicyclooctane (DBO) scaffold is the backbone of non-β-lactam-based second generation β-lactamase inhibitors. As part of our efforts, we have synthesized a series of DBO derivatives A1–23 containing amidine substituents at the C2 position of the bicyclic ring. These compounds, alone and in combination with meropenem, were tested against ten bacterial strains for their antibacterial activity in vitro. All compounds did not show antibacterial activity when tested alone (MIC >64 mg/L), however, they exhibited a moderate inhibition activity in the presence of meropenem by lowering its MIC values. The compound A12 proved most potent among the other counterparts against all bacterial species with MIC from a MIC value of 0.125 mg/L.
CYCLIC AMINE DERIVATIVE AND MEDICAL USE THEREOF
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Paragraph 0398-0403, (2020/12/25)
A cyclic amine derivative represented by general Formula (I): wherein R1 represents an alkyl group having 1 to 3 carbon atoms; A represents a group represented by general Formula (II-1), (II-2), or (II-3): R2 represents a hydrogen at
