178964-22-2Relevant academic research and scientific papers
Synthesis of E-selectin inhibitors: Use of an aryl-cyclohexyl ether as a disaccharide scaffold
Liu, Aijun,Dillon, Kathleen,Campbell, Robert M.,Cox, Don C.,Huryn, Donna M.
, p. 3785 - 3788 (2007/10/03)
A series of potential E-selectin antagonists were designed and synthesized based on the bound conformation of sLe(x), as well as the functional group requirements for anti-adhesion activity. A non carbohydrate scaffolding using an aryl-cyclohexyl ether which can orient the critical acid and fucose residues in appropriate positions has been investigated. The inhibitory activity of members of this series suggests the feasibility of non- carbohydrate E-selectin antagonists.
