178977-39-4

Basic information

• Product Name: (S)-3-[(R)-2-tert-Butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-2-methyl-propionic acid
• CAS NO: 178977-39-4
• Molecular Weight: 380.441
• Mol File: 178977-39-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-3-[(R)-2-tert-Butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-2-methyl-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-[(R)-2-tert-Butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-2-methyl-propionic acid(178977-39-4)
• EPA Substance Registry System: (S)-3-[(R)-2-tert-Butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-2-methyl-propionic acid(178977-39-4)

Safety Data

• Hazardous Substances Data: 178977-39-4(Hazardous Substances Data)

Upstream product

• 144-90-1 (S)-(+)-β²-homoalanine 
• 68856-96-2 N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine 

Downstream Products

• 178977-42-9 (S)-2-{(S)-3-[(R)-2-tert-Butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-2-methyl-propionyloxy}-4-methyl-pentanoic acid 

Relevant articles and documents

Synthesis and in vitro cytotoxicity of cryptophycins and related analogs

Several members of the Cryptophycin family were synthesised using a straightforward convergent approach. The proposed synthetic route was used to prepare novel analogs of Cryptophycins A and B in which the benzylic epoxide moiety was replaced by alternate electrophilic functions. The effect of these modifications on cytotoxic activity was determined on several tumor cell lines.