Synthesis and in vitro cytotoxicity of cryptophycins and related analogs

Article abstract of DOI:10.1016/0960-894X(96)00182-5

Several members of the Cryptophycin family were synthesised using a straightforward convergent approach. The proposed synthetic route was used to prepare novel analogs of Cryptophycins A and B in which the benzylic epoxide moiety was replaced by alternate electrophilic functions. The effect of these modifications on cytotoxic activity was determined on several tumor cell lines.