17899-33-1

Basic information

• Product Name: 2-imino-alpha-phenylthiazolidin-3-ethanol monohydrochloride
• Synonyms: 2-imino-alpha-phenylthiazolidin-3-ethanol monohydrochloride;Einecs 241-843-6;2-(2-iminothiazolidin-3-yl)-1-phenylethan-1-ol hydrochloride
• CAS NO: 17899-33-1
• Molecular Formula: C₁₁H₁₄N₂OS*ClH
• Molecular Weight: 258.7676
• EINECS: 241-843-6
• Mol File: 17899-33-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 224-225 °C
• Boiling Point: 380.1°Cat760mmHg
• Flash Point: 183.7°C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 2-imino-alpha-phenylthiazolidin-3-ethanol monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-imino-alpha-phenylthiazolidin-3-ethanol monohydrochloride(17899-33-1)
• EPA Substance Registry System: 2-imino-alpha-phenylthiazolidin-3-ethanol monohydrochloride(17899-33-1)

Safety Data

• Hazardous Substances Data: 17899-33-1(Hazardous Substances Data)

Usage

General Description

2-imino-alpha-phenylthiazolidin-3-ethanol monohydrochloride is a chemical compound commonly known as altizide. It is a thiazide diuretic used to treat hypertension and edema by increasing urine production and reducing the amount of water and salt in the body. Altizide works by inhibiting the reabsorption of sodium and chloride in the distal convoluted tubules of the kidneys, leading to increased excretion of water and electrolytes. It is often used in combination with other medications to achieve optimal blood pressure control. While altizide can be an effective treatment for certain conditions, it is important to use it under the guidance of a healthcare professional to monitor and manage any potential side effects.

Upstream product

• 5022-68-4 <(14)C>thiourea 
• 40371-21-9 N-(2-Chloraethyl)-N-(2-hydroxy-2-phenylaethyl)-amin 
• 17356-08-0 thiourea 
• 17918-11-5 1-(2'-hydroxy-2'-phenylethyl)aziridine 
• 463-56-9 thiocyanic acid 
• 82191-11-5 1-hydroxy-2-(2-oxotetrahydro-1,3-oxazol-3-yl)-1-phenylethane 

Downstream Products

• 112790-83-7 (S)-3-(2'-hydroxy-2'-phenylethyl)-2-thiazolidinimine 

Relevant articles and documents

Preparation method of tetramisole intermediate hydroxysalt

The invention relates to a preparation method of a tetramisole intermediate hydroxysalt in the technical field of broad-spectrum anthelmintics. The method comprises the following steps of: adding an aprotic solvent, acetophenone and inorganic base into a reaction device, performing heating, and stirring the substances uniformly; then adding 2-chloroethylamine hydrochloride into the reaction devicein batches, continuously carrying out heat preservation reaction, performing cooling and filtering after the reaction is finished, and carrying out vacuum concentration on filtrate to remove the solvent to obtain an oily compound; and adding water and the oily compound into a reaction device, adjusting the pH value by using hydrochloric acid to dissolve and clarify the material, adding thiourea,performing heating, distilling and concentrating until the internal temperature reaches 108-110DEG C, further carrying out reflux reaction, conducting cooling, crystallizing and filtering after the reaction is finished, washing the filter cake by using 95% ethanol, further performing filtering and drying, and drying the solid to obtain the hydroxysalt. The yield of the hydroxysalt can reach 90% orabove, the purity can reach 99% or above, the content can reach 98% or above, the preparation is convenient, the process is simple, and the method is an alternative method for industrial production of the hydroxysalt and tetramisole.

Preparation and addition of 3-bromo-2-oxotetrahydro-1,3-oxazoles to styrene and derivatives: Some new tetramisole intermediates

-

Process for preparing 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole

This disclosure relates to a process for the manufacture of compounds of the formula STR1 which comprises ring-closing a compound of the formula STR2 wherein the variables are as defined infra.