179017-53-9

Upstream product

• 179017-27-7 [2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid ethyl ester 
• 195873-29-1 [2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-(1,1-diethoxy-ethyl)-phosphinic acid ethyl ester 
• 179015-84-0 5'-O-(tert-butydiphenylsilyl)-3'-deoxy-3'-C-(iodomethyl)thymidine 
• 146557-80-4 1-{(3'R,4'S)-5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-3'-C-(hydroxymethyl)-β-pentofuranosyl}thymine 
• 146557-69-9 1-[5-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(formyl)-β-D-erythro-pentofuranosyl]thymine 

Downstream Products

• 342793-95-7 C₄₄H₅₂N₅O₁₂P 
• 197021-74-2 C₄₃H₅₀N₅O₁₂P 
• 197021-62-8 C₅₄H₆₈N₅O₁₀PSi₂ 
• 342793-93-5 C₅₅H₇₀N₅O₁₀PSi₂ 
• 197021-67-3 C₇₀H₈₄N₅O₁₂PSi₂ 

Relevant academic research and scientific papers

Synthesis and hybridisation properties of phosphonamidate ester modified nucleic acid

The replacement of the two backbone oxygen atoms of the phosphodiester linkage of DNA with carbon and nitrogen in the form of a phosphonamidate ester linkage, in both possible regioisomeric forms, is described. An alkylation reaction with the 3′-C-P-N-5′ methyl phosphonamidate regioisomer yielded the corresponding N-methylated analogues. For each example separation into individual phosphonamidate ester diastereoisomers was performed prior to incorporation into oligonucleotides. The effect upon duplex stability for DNA oligonucleotides containing each of these modifications with complimentary RNA is reported.