179052-82-5

Basic information

• Product Name: 2-acetoxy-1-benzyloxy-4-phenylpropane
• Synonyms: 2-acetoxy-1-benzyloxy-4-phenylpropane
• CAS NO: 179052-82-5
• Molecular Weight: 284.355
• Mol File: 179052-82-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-acetoxy-1-benzyloxy-4-phenylpropane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetoxy-1-benzyloxy-4-phenylpropane(179052-82-5)
• EPA Substance Registry System: 2-acetoxy-1-benzyloxy-4-phenylpropane(179052-82-5)

Safety Data

• Hazardous Substances Data: 179052-82-5(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 173917-50-5 3-(benzyloxy)-1-phenylpropan-2-ol 

Downstream Products

• 86551-93-1 (2S)-3-phenyl-propane-1,2-diol diacetate 
• 17131-14-5 (S)-(-)-3-phenyl-1,2-propanediol 
• 179052-75-6 2-acetoxy-3-phenylpropan-1-ol 

Relevant articles and documents

Kinetic resolution of 2-acylated-1,2-diols by lipase-catalyzed enantiomer selective acylation

Enantiomer selectivity of lipase catalyzed acylation of 2-acylated 1,2-diols was studied. First, acylation of 2-acetoxyheptan-1-ol rac-3b with vinyl acetate was investigated by varying the enzymes and the solvent, showing the highest enantiomer selectivity by using lipase from Pseudomonas fluorescens (PfL) in hexane-vinyl acetate (VA). We have found varying or even reversed enantiomer selectivity for different secondary acyl moieties in 2-acyloxyheptan-1-ols rac-3bA-F. Next, all six possible types of enantiomer selective biotransformations (hydrolysis of diacetate and the two kinds of monoacetetes; acylation of diol and the two kinds of monoacetates) were compared on two model diols rac-4b,d. Among the transformations investigated, acetylation of secondary monoacetates rac-3b,d showed the highest enantiomer selectivity. Finally, PfL catalyzed acetylations of several 2-acetylated 1,2-diols rac-3a-g were investigated under our optimum conditions.