173917-50-5Relevant articles and documents
TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS
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Page/Page column 234; 235, (2021/04/23)
Disclosed are a series of compounds or their tautomers having a general structure represented by Formula (la), (lb), (Ila), (lIb), or (lIc) and pharmaceutically acceptable salts thereof. The present disclosure also relates to pharmaceutical compositions comprising said compounds or tautomers. The present disclosure further relates to a method of treating a disease or condition associated with iron dysregulation or dysfunctional iron homeostasis comprising administering to a subject in need thereof a therapeutically effective amount of Formula (la), (lb), (Ila), (lIb), or (lIc) compounds or tautomers.
Nickel-catalyzed regiodivergent opening of epoxides with aryl halides: Co-catalysis controls regioselectivity
Zhao, Yang,Weix, Daniel J.
supporting information, p. 48 - 51 (2014/01/23)
Epoxides are versatile intermediates in organic synthesis, but have rarely been employed in cross-coupling reactions. We report that bipyridine-ligated nickel can mediate the addition of functionalized aryl halides, a vinyl halide, and a vinyl triflate to epoxides under reducing conditions. For terminal epoxides, the regioselectivity of the reaction depends upon the cocatalyst employed. Iodide cocatalysis results in opening at the less hindered position via an iodohydrin intermediate. Titanocene cocatalysis results in opening at the more hindered position, presumably via TiIII-mediated radical generation. 1,2-Disubstituted epoxides are opened under both conditions to form predominantly the trans product.
Pd-catalyzed cleavage of benzylic nitro bonds: New opportunities for asymmetric synthesis
Fessard, Thomas C.,Motoyoshi, Hajime,Carreira, Erick M.
, p. 2078 - 2081 (2008/02/13)
Without a trace: Benzylic nitroalkanes are reduced to the corresponding parent alkanes in good yields by using a simple procedure involving heterolytic C-N bond cleavage (see scheme). Traceless removal of the nitro group leaves behind a stereogenic center that may otherwise be difficult to install. This reaction significantly expands the scope of building blocks that can be accessed. (Chemical Equation Presented)
