179057-26-2

Usage

Uses

Used in Pharmaceutical Industry:
3-(1H-PYRAZOL-3-YL)BENZALDEHYDE is used as a key intermediate in the production of pyrazole derivatives, which are vital for the development of drugs. Its unique structure allows for the creation of compounds with potential therapeutic applications, making it an essential component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(1H-PYRAZOL-3-YL)BENZALDEHYDE serves as a crucial building block for the synthesis of pyrazole-based agrochemicals. These derivatives can be utilized in the development of pesticides and other agricultural chemicals, contributing to enhanced crop protection and yield.
Used in Fine Chemical Industry:
3-(1H-PYRAZOL-3-YL)BENZALDEHYDE is also employed as a key component in the synthesis of various fine chemicals. Its versatility in chemical reactions and the potential for creating a wide range of chemical entities make it an indispensable tool in the fine chemical industry for developing specialty chemicals with specific applications.

Upstream product

• 149739-51-5 3-pyrazol-3-ylbenzonitrile 
• 6136-68-1 3-acethylbenzonitrile 
• 179055-13-1 (E)-3-(3-(dimethylamino)acryloyl)benzonitrile 

Downstream Products

• 179056-29-2 (4-Methoxy-benzyl)-[3-(2H-pyrazol-3-yl)-benzyl]-amine 
• 179056-30-5 (4-Fluoro-benzyl)-[3-(2H-pyrazol-3-yl)-benzyl]-amine 
• 179056-17-8 N-benzyl-3-(pyrazol-3-yl)benzylamine 
• 179057-00-2 (2-Methoxy-benzyl)-[3-(2H-pyrazol-3-yl)-benzyl]-amine 
• 179057-01-3 (3-Methoxy-benzyl)-[3-(2H-pyrazol-3-yl)-benzyl]-amine 
• 179057-03-5 Phenethyl-[3-(2H-pyrazol-3-yl)-benzyl]-amine 
• 207909-16-8 Cycloheptyl-[3-(2H-pyrazol-3-yl)-benzyl]-amine 

Relevant academic research and scientific papers

Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA: Cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring

The synthesis, single crystal X-ray structural analysis, and biological activity of FR186054 (2c), a new, potent, orally efficacious inhibitor of acyl-CoA: cholesterol O-acyltransferase (ACAT), containing a pyrazole ring are described. This compound displ

Inhibitors of acyl-coA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N- (heteroaryl-substituted benzyl)-N'-arylureas

A series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylurea and related derivatives represented by 2 and 3 have been prepared and evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyltransferase in vitro and to lower plasma cholesterol levels in cholesterol-fed rats in vivo. Among these novel compounds, the type 3 series was superior. A pyrazol-3-yl group on the N-benzyl group of this trisubstituted urea (i.e. 3, Ar1 = pyrazol-3- yl) was identified as a heteroaromatic ring providing a good profile of biological activity. As a result of optimization of the combination with the N-alkyl group (R) and N-aryl group (At3), compound 3aq (FR186054) was identified as a new, orally efficacious ACAT inhibitor, which exhibited potent in vitro ACAT inhibitory activity (rabbit intestinal microsomes IC50 = 99 nM) and excellent hypocholesterolemic effects in cholesterol-fed rats, irrespective of administration mode (ED50 = 0.046 mg/kg dosed via the diet, ED50 = 0.44 mg/kg administered by gavage in PEG400 vehicle). Moreover, a toxicological study revealed compound 3aq to be nontoxic to the adrenal glands of dogs when tested at a single dose of 10 mg/kg po.