17910-73-5Relevant academic research and scientific papers
(R, S) - 2 - [[ 5 - (9- [...] carbonyl amino) dibenzo [a, d] cyclohepta-2-yl] oxy] method for the preparation of acetic acid (by machine translation)
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Paragraph 0027; 0044; 0046; 0050; 0052; 0056; 0058, (2020/05/05)
The invention relates to a preparation method of Ramage linker and mainly solves problems of long processes, complex post-treatment, much waste water, waste gas and solid waste, and high cost in a conventional synthetic method. The preparation method incl
(R, S)-2-[ [5-(9- [...] carbonyl amino) dibenzo [A, D] cyclohepta-2-yl] oxy] acetic acid synthesis process (by machine translation)
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, (2017/09/19)
The invention relates to a (R, S)-2-[ [5-(9- [...] carbonyl amino) dibenzo [A, D] cyclohepta-2-yl] oxy] acetic acid synthesis process, comprising the following steps: step one, O-carboxybenzaldehyde and Intergovernmental methoxylphenylboronic acetic acid in anhydrous sodium acetate under the catalysis of the reaction to obtain 2-(3-methoxy-vinyl) benzoic acid, Pd-C under the catalysis of the hydrogen reduction reaction-; step two, and SOCl 2 reaction to obtain 2-methoxy -10, 11-dihydro -5H-dibenzo [a, d] cycloheptene-5-one, then anhydrous AlCl 3 catalytic reflux reaction; step three, the return reaction of the intermediate product and bromine second grade acid benzyl ester for reaction; step four, the reduction reaction of the hydrogen gas, and then with Fmoc-NH 2 for reaction, to obtain. This invention, through optimization of the catalyst, is obviously improved the overall yield, effectively reducing the cost, is suitable for industrial mass synthesis application. (by machine translation)
Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): Potential modes of binding to the 5-HT2A receptor
Peddi, Srinivas,Roth, Bryan L.,Glennon, Richard A.,Westkaemper, Richard B.
, p. 2565 - 2568 (2007/10/03)
The synthesis and 5-HT2A receptor affinities of 2-substituted-5-aminomethyl-10,11-dihydrodibenzo[a,d]cycloheptene (AMDH) derivatives are described. Comparison of the effects of substitution on affinities allowed assignment of potential binding modes in comparison with DOB-like agonists/antagonists and 3-substituted 1-(aminomethyl)-9,10-dihydroanthracene structures.
Synthesis of 5--10,11-dihydrodibenzocyclohepten-2-yl>oxy>valeric Acid (CHA) and 5-dibenzocyclohepten-2-yl>oxy>valeric Acid (CHE) Handles for the Solid-Phase Synthesis of C-Terminal ...
Noda, Masaki,Yamaguchi, Minoru,Ando, Eiji,Takeda, Kenji,Nokihara, Kiyoshi
, p. 7968 - 7975 (2007/10/02)
Two novel handles for peptide amide preparation under mild conditions were developed for use in highly efficient solid-phase peptide sythesis.These handles, 5--10,11-dihydrodibenzocyclohepten-2-yl>oxy>valeric acid (CHA) and 5-dibenzocyclohepten-2-yl>oxy>valeric acid (CHE), were attached to the solid support and were used for syntheses of peptides having a C-terminal amide by the fluorenylmethoxycarbonyl strategy.The cleavability of CHA and CHE was determined and compared with the that commercially available amide handles.CHA and CHE handles can be rapidly cleaved from the polymer support without significant side reactions using lower acid concentrations than those required for conventional handles.As CHA can be easily synthesized in large amounts, it is suitable for peptide amide preparation for pharmaceuticals.As CHE can be cleaved at very low concentrations of acid, it is especially suitable for preparing side chain-protected peptide amides.Several brain-gut peptides having a C-terminal amide were synthesized in high yield and high purity with these novel handles.
