17922-79-1

Usage

Uses

Used in Pharmaceutical Development:
N-Cyclohexyl L-Z-ValinaMide is used as a key intermediate in the synthesis of pharmaceutical compounds for its ability to influence the stability, solubility, and pharmacokinetics of the final product.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, N-Cyclohexyl L-Z-ValinaMide serves as a valuable component in the design and development of new therapeutic agents, leveraging its potential to modulate biological activity.
Used in Drug Discovery:
N-Cyclohexyl L-Z-ValinaMide is utilized as a versatile chemical in drug discovery processes, where its unique structural features can be exploited to create novel and effective medications.
While the provided materials do not specify different industries for the uses of N-Cyclohexyl L-Z-ValinaMide, the general applications in pharmaceutical development, medicinal chemistry research, and drug discovery are common across these fields. If there are specific industry applications not covered in the materials, they would need to be researched and added separately.

Upstream product

• 72-18-4 L-valine 
• 501-53-1 benzyl chloroformate 
• 10512-93-3 Z-Val-ONp 
• 108-91-8 cyclohexylamine 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 

Downstream Products

• 132949-30-5 N-((2-hydroxy-1-naphthyl)methylene)-(S)-valine cyclohexylamide 
• 143592-34-1 Ps-S-Val-NHCy 
• 46339-96-2 L-N-cyclohexylvalinamide 

Relevant academic research and scientific papers

Synthesis, characterization and docking studies of anti-HCV molecules

The present study reports the synthesis and characterization of novel molecules inhibiting the spread of hepatitis C. The molecules were designed as to block the NS3/4A protease enzyme on HCV RNA. The molecules were synthesized using usual peptide synthesis techniques. Compounds with purity more than 95% were characterized and docking studies were also performed. All the compounds were characterized using physico-chemical techniques such as determination of melting point by DSC and NMR, mass, IR spectral studies. The docking studies were also conducted to assess the activity of molecules for inhibition of hepatitis C virus.

Stereoselectivity and regioselectivity in nucleophilic ring opening in derivatives of 3-phenylisoxazolo[2,3-a]pyrimidine. Unpredicted dimerization and ring transformation. Syntheses of derivatives of pyrimidinylmethylamine, pyrimidinylmethylamino acid ami

The nucleophilic ring opening of the isoxazolone ring in 2-oxo-3-phenylisoxazolo[2,3-a]pyrimidine derivatives by optically active amino acid amides and ephedrine led to pyrimidinylmethylamino acid amides. Using amides of different L-amino acids and (-)-ep

A catalyst for asymmetric induction

A catalyst for asymmetric induction is provided which comprises a titanium (IV) alkoxide and an amino acid amide derivative of formula (I): wherein R1 is isopropyl, isobutyl, sec-butyl, tert-butyl, phenyl or benzyl, R2 and R3 are the same or different and each is lower alkyl, C3 to C8 cycloalkyl, unsubstituted or substituted phenyl or hydrogen or R2 and R3 together form a divalent C3 to C7 alkylene group optionally containing one or more hetero atoms, R4 is chlorine, bromine, iodine, lower alkyl or unsubstituted or substituted phenyl, R5, R6 and R7 are the same or different and each is hydrogen, halogen, methyl or methoxy or R5 is as defined above and R6 and R7 together form -CH=CH-CH=CH- or -OCH2O- or R7 is as defined above and R5 and R6 together form -CH=CH-CH=CH- or -OCH2O- and * denotes an absolute configuration of S or R.

Peptide-titanium complex as catalyst for asymmetric addition of hydrogen cyanide to aldehyde

The complex of titanium ethoxide and an acyclic dipeptide ester whose terminal amino group is modified to a salicylal-type Schiff base catalyzes the asymmetric addition of hydrogen cyanide to aldehydes with high enantioselectivity. In the reaction of benzaldehyde and hydrogen cyanide, (R)-mandelonitrile is obtained with an enantiomeric excess of 90% when N-((2-hydroxy-1-naphthyl)methylene)-(S)-valyl-(S)-tryptophan methyl ester is employed. In place of the dipeptide, the amide derivatives of an amino acid modified by substituted salicylaldehyde, such as N-(3,5-dibromosalicylidene)-(S)-valine piperidide, exhibit an entirely opposite stereoselectivity to yield S-cyanohydrins with optical purities up to 97% ee. This novel peptide-titanium complex, therefore, enables us to afford optically active cyanohydrins of both absolute configurations by using natural S-amino acids as chiral auxiliaries.