10512-93-3

Usage

Uses

Used in Pharmaceutical Research:
Z-Val-ONP is used as a research tool for studying enzyme kinetics and mechanisms, given its role as an enzyme inhibitor or substrate. This aids in the development of new drugs and therapies by understanding the interactions between enzymes and their substrates or inhibitors.
Used in Drug Development:
In the pharmaceutical industry, Z-Val-ONP is used as a potential lead compound for the development of new drugs targeting specific enzymes. Its peptide functionalities allow for modifications and optimization to enhance its therapeutic effects and selectivity.
Used in Diagnostics:
Z-Val-ONP can be employed as a diagnostic agent in the development of assays and tests that measure enzyme activity or the presence of specific proteins in biological samples. Its biochemical properties make it suitable for such applications, contributing to the advancement of diagnostic techniques.
Used in Biochemical Education:
Z-Val-ONP serves as an educational tool in teaching biochemical concepts, such as enzyme kinetics, mechanisms of action, and the role of substrates and inhibitors in biological processes. Its structure and function provide a practical example for students to understand these complex topics.

InChI:InChI=1/C19H20N2O6/c1-13(2)17(20-19(23)26-12-14-6-4-3-5-7-14)18(22)27-16-10-8-15(9-11-16)21(24)25/h3-11,13,17H,12H2,1-2H3,(H,20,23)/t17-/m0/s1

Upstream product

• 25887-81-4 bis(p-nitrophenyl)sulfite 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 100-02-7 4-nitro-phenol 
• 7693-46-1 4-Nitrophenyl chloroformate 

Downstream Products

• 79598-35-9 benzyloxycarbonylvalyltyrosine ethyl ester 
• 6461-15-0 N²-(N-benzyloxycarbonyl-L-valyl)-N⁵-(toluene-4-sulfonyl)-L-ornithine methyl ester 
• 7352-28-5 N-(benzyloxycarbonyl)-L-valyl-L-threonine methyl ester 
• 52616-98-5 Cbz-Val-Leu-OtBu 
• 17708-79-1 (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)-4-methylpentanoic acid 
• 109570-28-7 Z-Val-Glu 
• 16876-04-3 Benzyloxycarbonyl-Val-His-OMe 
• 15149-72-1 N-(N-benzyloxycarbonyl-L-valyl)-L-tyrosine methyl ester 
• 129467-45-4 A 74704 
• 129467-48-7 (2S,3R,4S,5S)-2,5-Di-(N-(Cbz-valinyl)amino)-3,4-dihydroxy1,6-diphenylhexane 
• 129467-49-8 {(S)-1-[(1S,2S,3S,4S)-1-Benzyl-4-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-2,3-dihydroxy-5-phenyl-pentylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester 
• 129467-48-7 A-75925 
• 132307-34-7 Z-Val-Glu(OBu^t)-Arg-Tyr(Bu^t)-Leu-OH 
• 108807-63-2 Z-L-Val-L-prolinal semicarbazone 

Relevant academic research and scientific papers

Thermodynamic and (1)H NMR Study of Proton Complex Formation of Histidine-containing Cyclodipeptides in Aqueous Solution

A thermodynamic and (1)H NMR study of proton complex formation in aqueous solution of some L-histidine-containing cyclic L-dipeptides has been carried out.The enthalpic and entropic changes associated with protonation of the cyclodipeptides, obtained by potentiometric and calorimetric measurements, together with the (1)H NMR data and NOESY experiments, enable the role played by non-covalent interactions in proton complex formation to be assessed.In addition, a comparison with c(Gly-His) permits the influence of side-chain residues on the conformation of protonated species to be observed.

Dichlorotris(dimethylamino)phosphorane as Dehydration Reagent for the Preparation of Activated (-ONp, -OPcp, -NSu)Esters of N-Protected Multifunctional Amino Acids

Dichlorotris(dimethylamino)phosphorane (5) is an excellent reagent for the preparation of the activated esters of N-protected amino acids 7-9.Besides 4-nitrophenyl-, pentachlorophenyl-, and N-hydroxysuccinimide esters of various N-protected amino acids, in the presence of HOBt benzyloxycarbonyl-threonine N-hydroxysuccinimide ester was obtained for the first time.