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1793086-16-4

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1793086-16-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1793086-16-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,7,9,3,0,8 and 6 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1793086-16:
(9*1)+(8*7)+(7*9)+(6*3)+(5*0)+(4*8)+(3*6)+(2*1)+(1*6)=204
204 % 10 = 4
So 1793086-16-4 is a valid CAS Registry Number.

1793086-16-4Relevant articles and documents

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases

Zhang, Dong,Markoulides, Marios S.,Stepanovs, Dmitrijs,Rydzik, Anna M.,El-Hussein, Ahmed,Bon, Corentin,Kamps, Jos J.A.G.,Umland, Klaus-Daniel,Collins, Patrick M.,Cahill, Samuel T.,Wang, David Y.,von Delft, Frank,Brem, Jürgen,McDonough, Michael A.,Schofield, Christopher J.

supporting information, p. 2928 - 2936 (2018/04/19)

Metallo-β-lactamases (MBLs) enable bacterial resistance to almost all classes of β-lactam antibiotics. We report studies on enethiol containing MBL inhibitors, which were prepared by rhodanine hydrolysis. The enethiols inhibit MBLs from different subclasses. Crystallographic analyses reveal that the enethiol sulphur displaces the di-Zn(II) ion bridging ‘hydrolytic’ water. In some, but not all, cases biophysical analyses provide evidence that rhodanine/enethiol inhibition involves formation of a ternary MBL enethiol rhodanine complex. The results demonstrate how low molecular weight active site Zn(II) chelating compounds can inhibit a range of clinically relevant MBLs and provide additional evidence for the potential of rhodanines to be hydrolysed to potent inhibitors of MBL protein fold and, maybe, other metallo-enzymes, perhaps contributing to the complex biological effects of rhodanines. The results imply that any medicinal chemistry studies employing rhodanines (and related scaffolds) as inhibitors should as a matter of course include testing of their hydrolysis products.

Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredient

-

, (2008/06/13)

The rhodanine derivatives of the general formula: STR1 wherein (I) R1 and R2 are taken together to represent a tetramethylene or pentamethylene group; (II) R1 represents a hydrogen atom, and R2 represents (1) a

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