17938-70-4

Usage

Uses

Used in Pharmaceutical Industry:
1-IODO-2,3-DIMETHYL-4-METHOXYBENZENE is used as a reagent in the synthesis of various pharmaceutical compounds due to its ability to participate in reactions such as halogenation, nitration, and Suzuki coupling. Its role in the creation of new drug molecules is crucial for the development of novel treatments and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, 1-IODO-2,3-DIMETHYL-4-METHOXYBENZENE is utilized as a precursor in the production of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals that enhance crop protection and yield.
Used in Organic Synthesis:
1-IODO-2,3-DIMETHYL-4-METHOXYBENZENE is used as a key intermediate in organic synthesis for the preparation of a wide range of aromatic compounds. Its reactivity in various chemical reactions makes it a valuable component in the synthesis of specialty chemicals and materials for different applications.

Upstream product

• 2944-49-2 2,3-dimethylanisole 
• 17938-69-1 4-iodo-2,3-dimethyl-phenol 
• 77-78-1 dimethyl sulfate 
• 526-75-0 2,3-Dimethylphenol 
• 77375-19-0 2,3-dimethyl-4-methoxyaniline 

Downstream Products

• 17938-73-7 Dimethyl-6-iod-3-methoxy-phthalat 
• 1163305-83-6 5,6-dihydro-9-methoxy-6-methoxycarbonylmethyl-7,8-dimethyl-5-(4-methylbenzenesulfonyl)phenanthridine 
• 1148038-54-3 3-methoxy-1,2-dimethyl-9-(4-methylbenzenesulfonyl)-9H-carbazole 
• 1188273-01-9 3,4,2',3'-tetramethyl-5,4'-dimethoxy-2-(2-oxo-2-phenylethyl)-1,1'-biphenyl 

Relevant academic research and scientific papers

From catechol-tocopherol to catechol-hydroquinone polyphenolic antioxidant hybrids

Multidefence antioxidants represent a valuable solution for the protection against oxidative stress. From the planned synthesis of a catechol-tocopherol hybrid, we isolated a catechol-hydroquinone hybrid through a BBr3-mediated benzochromene-fluoren-1-ol transposition. The compound prepared showed a remarkable chain-breaking antioxidant in the catechol portion, while the very sensitive hydroquinone moiety revealed to be an efficient generator of hydroperoxyl radicals.

A direct palladium-catalyzed route to selectively substituted carbazoles through sequential C-C and C-N bond formation: Synthesis of carbazomycin A

The present paper offers a synthetically simple one-pot procedure for the catalytic preparation of the biologically interesting class of carbazoles. The new procedure is based on the combined catalysis of palladium and norbornene starting from o-substituted iodoarenes and N-sulfonylated or N-acetylated o-bromoanilines. A well-known member of this class, carbazomycin A, has been successfully prepared.

Iodination of Methylated Anisoles: Unusual Aryl Methyl Replacement and Oxidations

The treatment of methylated anisoles with iodine, periodic acid, sulfuric acid, and aqueous acetic acid has resulted in iododemethylations and/or aryl methyl oxidations in addition to the expected mono- and diiodinations of the aromatic ring.Four dimethylanisoles and o-methylanisole were treated under identical conditions.Iododemethylations were observed in three of the four dimethylanisoles and aryl methyl oxidations to benzaldehydes occured with o-methylanisole and two of the dimethylanisoles.No precedence could be found for either of these reactions under the experimental conditions employed.Several possible mechanisms are discussed for these transformations.Some experimental evidence suggests that methyl oxidation to a benzaldehyde could be a prerequisite for an iododemethylation via an iodonium ion-assisted reverse Gatterman-Koch reaction; single-electron-transfer or classical electrophilic mechanisms are also consistent with the iododemethylations.

Iodination of Aromatic Ethers by Use of Benzyltrimethylammonium Dichloroiodate and Zinc Chloride

The reaction of aromatic ethers with benzyltrimethylammonium dichloroiodate(1-) in acetic acid in the presence of zinc chloride at room temperature gave iodo-substituted aromatic ethers in good yields.