17938-70-4

Basic information

• Product Name: 1-IODO-2,3-DIMETHYL-4-METHOXYBENZENE
• Synonyms: 1-IODO-2,3-DIMETHYL-4-METHOXYBENZENE;4-IODO-2,3-DIMETHYLANISOLE;1-Iodo-4-Methoxy-2,3-diMethylbenzene
• CAS NO: 17938-70-4
• Molecular Formula: C₉H₁₁IO
• Molecular Weight: 262.09
• Mol File: 17938-70-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-IODO-2,3-DIMETHYL-4-METHOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-IODO-2,3-DIMETHYL-4-METHOXYBENZENE(17938-70-4)
• EPA Substance Registry System: 1-IODO-2,3-DIMETHYL-4-METHOXYBENZENE(17938-70-4)

Safety Data

• Hazardous Substances Data: 17938-70-4(Hazardous Substances Data)

Usage

General Description

1-Iodo-2,3-dimethyl-4-methoxybenzene, also known as 2,3-dimethyl-4-methoxy-1-iodobenzene, is an organic compound with the chemical formula C9H11IO and a molecular weight of 264.09 g/mol. It is a substituted phenyl iodide that is commonly used as a reagent in organic synthesis, particularly in the preparation of various aromatic compounds. This chemical can undergo reactions such as halogenation, nitration, and Suzuki coupling, and it is widely used in the pharmaceutical and agrochemical industries. It is a colorless to light yellow liquid at room temperature with a slightly sweet, musty odor, and it should be handled with care due to its potential to cause skin and eye irritation.

Upstream product

• 2944-49-2 2,3-dimethylanisole 
• 77375-19-0 2,3-dimethyl-4-methoxyaniline 
• 526-75-0 2,3-Dimethylphenol 
• 17938-69-1 4-iodo-2,3-dimethyl-phenol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 17938-73-7 Dimethyl-6-iod-3-methoxy-phthalat 
• 1148038-54-3 3-methoxy-1,2-dimethyl-9-(4-methylbenzenesulfonyl)-9H-carbazole 
• 1188273-01-9 3,4,2',3'-tetramethyl-5,4'-dimethoxy-2-(2-oxo-2-phenylethyl)-1,1'-biphenyl 
• 1163305-83-6 5,6-dihydro-9-methoxy-6-methoxycarbonylmethyl-7,8-dimethyl-5-(4-methylbenzenesulfonyl)phenanthridine 

Relevant articles and documents

From catechol-tocopherol to catechol-hydroquinone polyphenolic antioxidant hybrids

Multidefence antioxidants represent a valuable solution for the protection against oxidative stress. From the planned synthesis of a catechol-tocopherol hybrid, we isolated a catechol-hydroquinone hybrid through a BBr3-mediated benzochromene-fluoren-1-ol transposition. The compound prepared showed a remarkable chain-breaking antioxidant in the catechol portion, while the very sensitive hydroquinone moiety revealed to be an efficient generator of hydroperoxyl radicals.

Iodination of Methylated Anisoles: Unusual Aryl Methyl Replacement and Oxidations

The treatment of methylated anisoles with iodine, periodic acid, sulfuric acid, and aqueous acetic acid has resulted in iododemethylations and/or aryl methyl oxidations in addition to the expected mono- and diiodinations of the aromatic ring.Four dimethylanisoles and o-methylanisole were treated under identical conditions.Iododemethylations were observed in three of the four dimethylanisoles and aryl methyl oxidations to benzaldehydes occured with o-methylanisole and two of the dimethylanisoles.No precedence could be found for either of these reactions under the experimental conditions employed.Several possible mechanisms are discussed for these transformations.Some experimental evidence suggests that methyl oxidation to a benzaldehyde could be a prerequisite for an iododemethylation via an iodonium ion-assisted reverse Gatterman-Koch reaction; single-electron-transfer or classical electrophilic mechanisms are also consistent with the iododemethylations.