179532-63-9Relevant academic research and scientific papers
Synthesis of (+)-biotin derivatives as HIV-1 protease inhibitors
Han, Qi,Lafontaine, Jennifer,Bacheler, Lee T.,Rayner, Marlene M.,Klabe, Ronald M.,Erickson-Viitanen, Susan,Lam, Patrick Y.S.
, p. 1371 - 1374 (2007/10/03)
Several bis-N-alkylated (+)-biotin derivatives were synthesized and evaluated for activities against HIV-1 protease. The most potent inhibitor, 2D, synthesized in two steps from (+)-biotin, has K(i) of 0.50 μM and antiviral IC90 of 7 μM. The (+
