179532-65-1Relevant academic research and scientific papers
An efficient epimerization of biotin sulfone derivatives to 2-epi-biotin analogs
Oh, Kyungsoo
, p. 3685 - 3688 (2008/02/03)
Reduction of biotin sulfone derivatives leads to 2-epi-biotin analogs. The stereochemistry of the side chain at C2 can be simply deduced from the diagnostic chemical shift pattern of the benzylic protons, rather than through the conventional an
Synthesis of (+)-biotin derivatives as HIV-1 protease inhibitors
Han, Qi,Lafontaine, Jennifer,Bacheler, Lee T.,Rayner, Marlene M.,Klabe, Ronald M.,Erickson-Viitanen, Susan,Lam, Patrick Y.S.
, p. 1371 - 1374 (2007/10/03)
Several bis-N-alkylated (+)-biotin derivatives were synthesized and evaluated for activities against HIV-1 protease. The most potent inhibitor, 2D, synthesized in two steps from (+)-biotin, has K(i) of 0.50 μM and antiviral IC90 of 7 μM. The (+
