179537-92-9Relevant academic research and scientific papers
Proteasome inhibitors for cancer therapy
Iqbal, Mohamed,Messina McLaughlin, Patricia A.,Dunn, Derek,Mallya, Satish,Husten, Jean,Ator, Mark A.,Chatterjee, Sankar
, p. 2362 - 2368 (2012/05/20)
Proteasome, a large multicatalytic proteinase complex that plays an important role in processing of proteins, has been shown to possess multiple catalytic activities. Among its various activities, the 'chymotrypsin-like' activity of proteasome has emerged as the focus of drug discovery efforts in cancer therapy. Herein we report chiral boronate derived novel, potent, selective and cell-permeable peptidomimetic inhibitors 6 and 7 that displayed activity against various rodent and human tumor cell lines (in vitro).
Multicatalytic protease inhibitors
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, (2008/06/13)
Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: STR1 Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.
