17959-90-9

Usage

Structure

Bicyclic heterocyclic compound
Contains a benzene ring fused to an oxazinone ring

Use in Synthesis

Pharmaceutical and organic compounds
Acts as an intermediate or building block in the synthesis of various pharmaceuticals and organic molecules

Biological and Pharmacological Activities

Potential applications
Studied for its possible effects on biological systems and potential therapeutic uses

Research and Industrial Applications

Unique structural and chemical properties
Utilized in various research and industrial settings due to its distinct properties

Field of Relevance

Chemistry and pharmacology
A significant chemical compound with a variety of potential applications and uses in these fields

Upstream product

• 17959-87-4 2-(2-chloro-propionylamino)-4-methyl-phenol 
• 1248141-64-1 2-(4-methyl-2-nitrophenoxy)propanenitrile 
• 119-33-5 4-methyl-2-nitrophenol 
• 95-84-1 3-amino-4-hydroxytoluene 
• 535-11-5 Ethyl 2-bromopropionate 

Downstream Products

• 52042-29-2 4-(2,3-dihydroxy-propyl)-2,6-dimethyl-4H-benzo[1,4]oxazin-3-one 
• 17959-83-0 2-[2-(3,4-Dichloro-benzoylamino)-4-methyl-phenoxy]-propionic acid 

Relevant academic research and scientific papers

Microwave-assisted one-pot regioselective synthesis of 2-alkyl-3,4-dihydro- 3-oxo-2H-1,4-benzoxazines

A protocol for regioselective one-pot synthesis of 2-alkyl-3,4-dihydro-3- oxo-2H-1,4-benzoxazines under controlled microwave heating has been developed. Starting from commercially available 2-aminophenols, a base-mediated regioselective O-alkylation took

A simple and facile route for the synthesis of 2H-1,4-benzoxazin-3-(4H)- ones via reductive cyclization of 2-(2-nitrophenoxy)acetonitrile adducts in the presence of Fe/acetic acid

A simple route for the synthesis of 1,4-benzoxazin-3-(4H)-ones is described herein. This method involves the reductive cyclization of 2-(2-nitrophenoxy) acetonitrile adducts in the presence of Fe/acetic acid in good to excellent yields. This system was compatible with various other functional groups.

[Omim][BF4], a green and recyclable ionic liquid medium for the one-pot chemoselective synthesis of benzoxazinones

An efficient procedure for the one-pot chemoselective synthesis of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives from their corresponding o-aminophenols is developed using DBU in the ionic liquid [omim][BF4]. Upon completion of the reaction and separation of the product, the ionic liquid is recovered and successfully reused over nine recycles without any noticeable loss of performance.

Synthesis and pharmacological activity of 4 substituted 2,3 dihydro 1,4 benzoxazin 3 ones

Some derivatives of 3 oxo 2,3 dihydro 1,4 benzoxazine substituted with aminoalkyl and hydroxyalkyl groups were prepared and their analgesic activity studied. This was weak for the amino, but very important for the propranediol derivatives. One of them, AN