179600-36-3

Upstream product

• 234122-92-0 (2R,4R)-3-tert-butoxycarbonyl-2-(4-tert-butyldimethylsilyloxy-but-2-ynoil)-4-phenyl-1,3-oxazolidine 
• 179600-33-0 [2R,2(1S),4R]-3-tert-butoxycarbonyl-2-(4-tert-butyldimethylsilyloxy-1-hydroxy-but-2-ynyl)-4-phenyl-1,3-oxazolidine 
• 164530-42-1 (2R,4R)-2-carboxy-4-phenyl-3-tert-butoxycarbonyloxazolidine 
• 56613-80-0 D-2-phenylglycinol 
• 151-50-8 potassium cyanide 

Downstream Products

• 208649-02-9 (2S,3S)-3-hydroxypipecolic acid 
• 179600-37-4 (4R,9S,9aS)-9-Benzyloxy-4-phenyl-3,4,9,9a-tetrahydro-6H-pyrido[2,1-c][1,4]oxazin-1-one 

Relevant academic research and scientific papers

Cyclization of a chiral oxazolidine as a key-step for the synthesis of functionalized piperidines

Bicyclic oxazolidine 6, a potential precursor for the synthesis of enantiopure piperidines and indolizidines, was synthesized from (R)-phenylglycinol. A stereoselective addition of cyanide anion on this compound afforded ultimately (2S,3S)-3-hydroxypipecolic acid 9.