Cyclization of a chiral oxazolidine as a key-step for the synthesis of functionalized piperidines

DOI: 10.1016/0040-4039(96)00767-8

Source and publish data:

Tetrahedron Letters p. 4001 - 4002 (1996)

Update date:2022-07-29

Topics:

Authors:

Agami, Claude

Couty, Francois

Mathieu, Helene

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Article abstract of DOI:10.1016/0040-4039(96)00767-8

Bicyclic oxazolidine 6, a potential precursor for the synthesis of enantiopure piperidines and indolizidines, was synthesized from (R)-phenylglycinol. A stereoselective addition of cyanide anion on this compound afforded ultimately (2S,3S)-3-hydroxypipecolic acid 9.

Full text of DOI:10.1016/0040-4039(96)00767-8

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