17965-74-1

Usage

Uses

Used in Pharmaceutical Synthesis:
8-Bromo-1,6-naphthyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 8-Bromo-1,6-naphthyridine serves as a crucial component in the production of pesticides and other crop protection agents. Its incorporation into these products enhances their effectiveness in controlling pests and diseases, thereby contributing to increased agricultural productivity.
Used in Organic Reactions as a Reagent:
8-Bromo-1,6-naphthyridine is also utilized as a reagent in various organic reactions, such as bromination, cyclization, and coupling reactions. Its presence can facilitate the formation of desired products and improve the overall efficiency of these chemical processes.

InChI:InChI=1/C8H5BrN2/c9-7-5-10-4-6-2-1-3-11-8(6)7/h1-5H

Upstream product

• 253-72-5 1,6-naphthyridine 
• 504-24-5 4-aminopyridine 

Downstream Products

• 6052-72-8 5,6,9,10-tetrahydro-4H,8H-pyrido[3,2,1-ij][1,6]naphthyridine 

Relevant academic research and scientific papers

HETEROARYL COMPOUNDS AS CXCR4 INHIBITORS, COMPOSITION AND METHOD USING THE SAME

The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to the CXCR4 pathway.

Modular design of pyridine-based acyl-transfer catalysts

Derivatives of 3,4-diaminopyridine have been synthesized and studied as catalysts for acyl-transfer reactions. The design of these catalysts is guided by the stability of their acetyl intermediates as determined through theoretical calculations at the B3LYP/6-311 + G(d,p)//B3LYP/6-31G(d) level of theory. The most promising catalysts have been synthesized through a three- to five-step synthesis starting from 3,4-diaminopyridine. The catalytic activity has been determined for the acylation of 1-ethynylcyclohexanol with acetic anhydride at 23°C and with isobutyric anhydride at 40°C. For both reactions, the catalytic activity depends dramatically on the substitution pattern of the diaminopyridines. Best results are obtained with catalysts containing alkyl substituents at both amine nitrogens. Georg Thieme Verlag Stuttgart.

ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION

Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise (I) wherein: Ra, R1, R2 and R3 are each, independently, hydrogen, or a substituent selected from halogen, CF3, alkyl, alkoxy, MeSO2, amino or aminocarbonyl (each optionally substituted by one or two groups selected from alkyl and benzyl) carboxy, or alkoxycarbonyl; or two adjacent of Ra and R1-4 together can form a 5-7 membered carbocyclic or heterocyclic ring which is optionally substituted by a substituent defined above; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, arylalkyl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, alkoxy or benzyloxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is CH or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.

Condensed Heteroaromatic Ring Systems. V. Formal Synthesis of Matrine and Related Compounds Using Palladium-Catalyzed Carbon-Carbon Bond Formations as Key Reactions

The iodonation and subsequent dehydroxychlorination of 1,6-naphthyridin-5(6H)-one gave 5-chloro-8-iodo-1,6-naphthyridine, wich was converted to the 5-methoxy derivative.Starting from this compound, didehydromatrine was synthesized by using palladium-catalyzed cross-coupling reactions with ethyl acrylate and 3-butyn-1-ol, as key reactions.Similarly, nordehydro-α-matrinidine was synthesized through four steps from 8-bromo-1,6-naphthyridine, obtained by the bromination of unsubstituted 1,6-naphthyridine.Keywords - synthesis; matrine; didehydromatrine; nordehydro-α-matrinidine; palladium-catalyzed reaction; 1,6-naphthyridine; ethyl acrylate; 3-butyn-1-ol