17965-80-9

Usage

Uses

Used in Pharmaceutical Industry:
[1,5]-NAPHTHYRIDIN-2-YLAMINE is used as a building block in organic synthesis for the preparation of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, [1,5]-NAPHTHYRIDIN-2-YLAMINE serves as a crucial intermediate in the synthesis of agrochemicals. Its incorporation in the development process can lead to the creation of effective pesticides and other agricultural products.
Used in Fine Chemicals Synthesis:
[1,5]-NAPHTHYRIDIN-2-YLAMINE is also utilized in the synthesis of fine chemicals, which are high-purity chemicals used in various applications, including research, chemical analysis, and the production of specialty products.
Used in Antiviral and Antibacterial Applications:
[1,5]-NAPHTHYRIDIN-2-YLAMINE has been reported to exhibit antiviral and antibacterial activities, making it a potential candidate for drug development in the field of infectious diseases. Its ability to combat viruses and bacteria positions it as a valuable asset in the creation of new therapeutic agents.
Used in Fluorescent Dyes and Materials Development:
Furthermore, [1,5]-NAPHTHYRIDIN-2-YLAMINE has been studied for its potential use in the development of novel fluorescent dyes and materials. Its properties make it a promising candidate for applications in bioimaging, sensing, and other areas where fluorescent标记 compounds are required.

InChI:InChI=1/C8H7N3/c9-8-4-3-6-7(11-8)2-1-5-10-6/h1-5H,(H2,9,11)

Upstream product

• 4214-76-0 5-nitro-pyridin-2-ylamine 
• 462-08-8 pyridin-3-ylamine 
• 152562-95-3 S,S-dimethyl-N-(1,5-naphthyridin-2-yl)sufilimine 
• 254-79-5 1,5-naphthyridine 
• 4318-76-7 pyridine-2,5-diamine 
• 56-81-5 glycerol 

Downstream Products

• 10261-82-2 1,5-naphthyridin-2(1H)-one 
• 38956-59-1 2-acetamido-1,5-naphthyridine 
• 1351516-11-4 1-amino-1,5-naphthyridin-2(1H)-iminium-2,4,6-trimethyl-benzenesulfonate 
• 1428879-19-9 C₂₁H₁₄N₄O₂S 
• 1446509-95-0 2-((1R,2S)-2-amino-cyclohexylamino)-thieno[3,2-d]pyrimidine-7-carboxylic acid [1,5]naphthyridin-2-ylamide 

Relevant academic research and scientific papers

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes

Amination and Synthesis of Some Nitronaphthyridines

3-Nitro and 3,6-dinitro-1,8-naphthyridines 1, 4 and 5 are dehydroaminated with a liquid ammonia solution of potassium permanganate to the corresponding 4-amino-substituted compounds 3, 8 and 9.The intermediate 4-amino ?-adducts 2,6 and 7 of the nitro-1,8-naphthyridines are detected by 1H-NMR spectroscopy.The syntheses of some nitro-substituted naphthyridines are described. Key Words: Amination / Amino ?-adducts / Naphthyridines

Chichibabin Amination of 1,X-Naphthyridines. Nuclear Magnetic Resonance Studies on the ? Adducts of Heterocyclic Systems with Nucleophiles

In the amination of 1,X-naphthyridines with potassium amide in liquid ammonia at about -35 to -40 deg C the initial adduct formation is charge controlled.Thus, at these temperatures the site with the lowest electron density is most susceptible for amide attack (C-2 in 1,5-naphthyridine, C-2 in 1,6-naphthyridine, C-2 and C-8 in 1,7-naphthyridine, and C-2 in 1,8-naphthyridine), as proven by NMR spectroscopy.When the temperature was raised to about 10 deg C, the site of addition has been found to change for 1,5- and 1,7-naphthyridine (NMR spectroscopy): from C-2 to C-4 in 1,5-naphthyridine and from C-2 and C-8 to C-8 only in 1,7-naphthyridine.In case of 1,6- and 1,8-naphthyridines no change was observed.Thus, the amination at about 10 deg C is a process which is thermodynamically controlled.The several factors which contribute to the stability of these addition products have been discussed.It has been found that the anionic ? adducts 2(4,8)-aminodihydro-1,X-naphthyridinides can be easily oxidized with potassium permanganate into their corresponding 2(4,8)-amino-1,X-naphthyridines.