4318-76-7

Usage

Uses

Used in Pharmaceutical Industry:
2,5-Diaminopyridine is used as a chemical intermediate for the preparation of 6-acetamidoimidazo[1,2-a]pyridine, which is a significant compound in the development of pharmaceuticals. Its role in this application is to facilitate the synthesis of therapeutically relevant molecules.
Used in Polymer Industry:
2,5-Diaminopyridine is used as a monomer in the preparation of organo-soluble polyimides by reacting with different dianhydride monomers. These polyimides are known for their high thermal stability and mechanical properties, making them suitable for various applications, such as in the electronics and aerospace industries.
Used in Material Science:
2,5-Diaminopyridine serves as a precursor for preparing novel polyimide-silica composites. These composites exhibit enhanced properties, such as improved thermal stability and mechanical strength, which can be utilized in various high-performance applications, including coatings, adhesives, and membranes.

InChI:InChI=1/C5H7N3/c6-4-1-2-5(7)8-3-4/h1-3H,6H2,(H2,7,8)

Upstream product

• 4663-96-1 pyridine-2,5-dicarboxylic acid diamide 
• 122196-45-6 N,N'-pyridine-2,5-diyl-bis-carbamic acid diethyl ester 
• 7647-01-0 hydrogenchloride 
• 4214-76-0 5-nitro-pyridin-2-ylamine 
• 69080-06-4 2-azido-5-nitropyridine 
• 137347-01-4 3-ethoxy-2-bromo-6-nitro-pyridine 
• 624-28-2 2,5-dibromopyridine 

Downstream Products

• 88854-59-5 C₂₀H₂₂N₆O₅ 
• 156358-97-3 N-(6-amino-3-pyridyl)-N'-cyano-O-phenylisourea 
• 54012-73-6 3-aminopiperidine 
• 71119-18-1 2,5-bis-sulfanilylamino-pyridine 
• 17103-45-6 sulfanilic acid-(6-amino-[3]pyridylamide) 
• 3131-52-0 1H-indole-5,6-diol 
• 925898-42-6 N₃-(6-aminopyridin-3-yl)-N₁-(2-cyclopentylethyl)-4-methylisophthalamide 
• 874491-91-5 2,5-bis-[(N-acetyl-sulfanilyl)-amino]-pyridine 
• 17965-80-9 2-amino-1,5-naphthyridine 
• 69952-40-5 N,N′-(pyridine-2,5-diyl)dibenzamide 
• 113063-26-6 2,5-bis-salicylidenamino-pyridine 

Relevant academic research and scientific papers

Homogenous bimetallic catalysis on amination of ArX and ArX2 in aqueous medium-synergistic effect of dicopper complexes

A dicopper complex [Cu2(bpnp)(OH)(CF3COO) 3] (1) (bpnp = 2,7-bis(pyridin-2-yl)-l,8-naphthyridine) was found to be an excellent catalyst on amination of aryl halides and aryl dihalides with ammonia in aqueous solutions leading to the corresponding anilines and aryldiamines, respectively. Catalytic activity of 1 toward amination appears to be superior to those of other mono nuclear copper complexes. Furthermore, the bimetallic catalyst 1 gave exclusively diamination product in the reaction of ArX2 with ammonia, but other copper complexes showed poor selectivity. Kinetic product distribution study suggests that the dicopper metal ions in this catalysis promote the second amination efficiently.

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes

1,3-Dihydroxybenzene derivatives and colorants containing said compounds

1,3-Dihydroxybenzene derivatives of general formula (I) or (Ia) or physiologically tolerated, water-soluble thereof wherein R′1 denotes substituted pyridyl group, a pyrimidyl group, a group of formula (IIa) or (IIIa) and the dyeing agents for keratin fibers containing these compounds.

One step hair coloring compositions using salts

A hair coloring composition comprising the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an amino phenol, a naphthol, a polyhydric phenol, a catechol and mixtures thereof; wherein the composition comprising one or more oxidative hair coloring agents further comprises al least one water soluble carbonate releasing salts; and optionally a water soluble ammonium salt, is described.

Transition metal complexes as dye forming catalysts in hair coloring compositions

A hair coloring composition comprising a first composition which comprises: (a) a dye forming transition metal salt or complex; which is first applied to the hair; and a second composition which comprises the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an aminophenol, a polyhydric phenol a catechol and mixtures thereof.

Enhanced color deposition for hair with sequestering agents

Hair coloring compositions which comprise: (A) non-nitrogenous chelating agents from the group consisting of polyphosphate; phosphonates; hydroxycarboxylates; polyacrylates; zeolite; and mixtures thereof; (B) an oxidative dye primary intermediate; and (C) an oxidative dye coupler; (D) and water are described. The present invention also relates to a method for coloring hair which comprises contacting said hair with a hair coloring composition as described above.

Amination of aryl halides using copper catalysis

Bromopyridine 4 was converted into aminopyridine 5 under Cu2O catalysis with an ethylene glycol solution of ammonia in excellent yield (90%). The amination reaction features low (0.5 mol%) catalyst loading, mild reaction temperature (80°C) and low reaction pressure (50 psi). This protocol is further studied in the amination of a variety of aryl halides.

Indium Mediated Reduction of Nitro and Azide Groups in the Presence of HCl in Aqueous Media

Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room temperature in aqueous THF successfully provided the corresponding amine in high to quantitative yields. Under the some reaction conditions, selective reduction of azide and nitro group in the presence of vinyl group could be accomplished.

Structure-activity relationships for the antileishmanial and antitrypanosomal activities of 1'-substituted 9-anilinoacridines

Members of the class of 9-anilinoacridine topoisomerase II inhibitors bearing lipophilic electron-donating 1'-aniline substituents are active against both the promastigote and amastigote forms of the parasite Leishmania major. A series of analogues of the known 1'-NHhexyl lead compound were prepared and evaluated against L. major in macrophage culture to further develop structure-activity relationships (SAR). Toxicity toward mammalian cells was measured in a human leukemia cell line, and the ratio of the two IC50 values (IC50(J)/IC50(L)) was used as a measure of the in vitro therapeutic index (IVTI). A 3,6-diNMe2 substitution pattern on the acridine greatly increased toxicity to L. major without altering mammalian toxicity, increasing IVTIs over that of the lead compound. The 2-OMe, 6-C1 acridine substitution pattern used in the antimalarial drug mepacrine also resulted in potent antileishmanial activity and high IVTIs. Earlier suggestions of the utility of 2'-OR groups in lowering mammalian cytotoxicity were not borne out in this wider study. A series of very lipophilic 1'-NRR (symmetric dialkylamino)-substituted analogues showed relatively high antileishmanial potency, but no clear trend was apparent across the series and none were superior to the 1'-NH(CH2)5Me subclass. Subsets of the most active 1'- N(R)(CH2)5Me- and 1'-N(alkyl)2-substituted compounds against L. major were also evaluated against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei, but no consistent SAR could be discerned in these physiologically diverse test systems. The present study has confirmed earlier conclusions that lipophilic electron-donating groups at the 1'-position of 9- anilinoacridines provide high activity against L. major, but the SAR patterns observed do not carry over to the other parasites studied.