179691-21-5

Basic information

• Product Name: Carbonochloridic acid, 2-(2-nitrophenyl)ethyl ester
• CAS NO: 179691-21-5
• Molecular Formula: C9H8ClNO4
• Molecular Weight: 229.62
• Mol File: 179691-21-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbonochloridic acid, 2-(2-nitrophenyl)ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonochloridic acid, 2-(2-nitrophenyl)ethyl ester(179691-21-5)
• EPA Substance Registry System: Carbonochloridic acid, 2-(2-nitrophenyl)ethyl ester(179691-21-5)

Safety Data

• Hazardous Substances Data: 179691-21-5(Hazardous Substances Data)

Upstream product

• 75-44-5 phosgene 
• 15121-84-3 2-nitro-benzeneethanol 
• 88-72-2 1-methyl-2-nitrobenzene 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 179691-36-2 5'-O-(2-(2-nitrophenyl)ethoxycarbonyl)thymidine 

Relevant articles and documents

New photolabile protecting groups of the 2-(2- nitrophenyl)ethoxycarbonyl-and the 2-(2-nitrophenyl)ethylsulfonyl-type for the oligonucleotide synthesis

New photolabile blocking groups have been synthesized and introduced into the 5'-OH position of thymidine. The 5'-O-protected thymidines were irradiated at 365 nm under identical conditions and the half-lives and thymidine yields were determined to investigate the influence of different substituents in the two corresponding series.

Nucleoside derivatives with photolabile protective groups

The invention relates to nucleoside derivatives having photolabile protective groups of the general formula (I) STR1 in which R1 =H, NO2, CN, OCH3, halogen or alkyl or alkoxyalkyl having 1 to 4 C atoms R2 =H, OCH3 R3 =H, F, Cl, Br, NO2 R4 =H, halogen, OCH3, or an alkyl radical having 1 to 4 C atoms R5 =H or a usual functional group for preparing oligonucleotides R6 =H, OH, halogen or XR8, where X=O or S and R8 represents a protective group usual in nucleotide chemistry, B=adenine, cytosine, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazolcarboxamid-1-yl, or 5-amino-4-imidazolcarboxamid-3-yl, where in the case of B=adenine, cytosine or guanine, the primary amino function optionally exhibits a permanent protective group. These derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.

Photolabile protecting groups for nucleosides: Synthesis and photodeprotection rates

o-Nitrobenzyloxycarbonyl and a number of related groups have been tested for the photolabile protection of nucleoside 5'-hydroxyls. The rates of photodeprotection were found to vary by approximately 17-fold in a series of 5'-O-protected thymidine derivati