179693-93-7

Upstream product

• 179693-92-6 N,N'-bis(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxyterephthalamide 
• 7169-12-2 2,3-dimethoxyterephthalic acid chloride 

Downstream Products

• 179693-94-8 2,2'-(2,3-diethyl-1,4-phenylene)bis(4,4-dimethyl-2-oxazoline) 
• 341556-97-6 3,3'-(2,3-diethyl-1,4-phenylene)bisacrylic acid 
• 179693-96-0 2,3-diethylterephthalaldehyde 

Relevant academic research and scientific papers

Novel seco cyclopropa[c]pyrrolo[3,2-e]indole bisalkylators bearing a 3,3′-arylenebisacryloyl group as a linker

We synthesized the novel seco cyclopropa[c]pyrrolo[3,2-e]indole (CPI) bisalkylators and evaluated their antitumor activity. Among these derivatives, 11a (AT-760), in which the two seco 3-methoxycarbonyl-2-trifluoromethyl CPI (MCTFCPI) moieties are connected with a 3,3′-(1,4-phenylene)bisacryloyl group, was found to exhibit more potent cytotoxicity and antitumor activity against HeLaS3 human uterine cervix carcinoma cells and Colon 26 adenocarcinoma cells, respectively, than 8 (bizelesin, U-77,779). It also appeared that compound 11a exhibits improved in vivo efficacy in the human colon CX-1 model when compared to either compound 8 or mitomycin C (MMC). Efficacious doses for 11a were found to be 2-fold lower than those for 8.

Acrylamide derivatives and process for production thereof

Acrylamide derivatives represented by General Formula (1) below: STR1 (One specific example of General Formula (1) is methyl (S,S)-3,3'-?3,3'-(1,4-phenylenediacryloyl)!-bis?1-chloromethyl-5-hydroxy-7-triflouromethyl-1, 2,3,6-tetrahydropyrrolo?3,2-e!indole-8-carboxylate.) The acrylamide derivatives represented by General Formula (1) is highly selective to cancer cells, less toxic, and highly active also against solid tumor.