179693-92-6

Basic information

• Product Name: N,N'-bis(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxyterephthalamide
• Synonyms: N,N'-bis(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxyterephthalamide
• CAS NO: 179693-92-6
• Molecular Weight: 368.43
• Mol File: 179693-92-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N,N'-bis(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxyterephthalamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-bis(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxyterephthalamide(179693-92-6)
• EPA Substance Registry System: N,N'-bis(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxyterephthalamide(179693-92-6)

Safety Data

• Hazardous Substances Data: 179693-92-6(Hazardous Substances Data)

Upstream product

• 7169-12-2 2,3-dimethoxyterephthalic acid chloride 
• 124-68-5 2-Amino-2-methyl-1-propanol 

Downstream Products

• 179693-94-8 2,2'-(2,3-diethyl-1,4-phenylene)bis(4,4-dimethyl-2-oxazoline) 
• 341556-97-6 3,3'-(2,3-diethyl-1,4-phenylene)bisacrylic acid 
• 179693-96-0 2,3-diethylterephthalaldehyde 
• 179693-93-7 2,2'-(2,3-dimethoxy-1,4-phenylene)bis(4,4-dimethyl-2-oxazoline) 

Relevant articles and documents

Novel seco cyclopropa[c]pyrrolo[3,2-e]indole bisalkylators bearing a 3,3′-arylenebisacryloyl group as a linker

We synthesized the novel seco cyclopropa[c]pyrrolo[3,2-e]indole (CPI) bisalkylators and evaluated their antitumor activity. Among these derivatives, 11a (AT-760), in which the two seco 3-methoxycarbonyl-2-trifluoromethyl CPI (MCTFCPI) moieties are connected with a 3,3′-(1,4-phenylene)bisacryloyl group, was found to exhibit more potent cytotoxicity and antitumor activity against HeLaS3 human uterine cervix carcinoma cells and Colon 26 adenocarcinoma cells, respectively, than 8 (bizelesin, U-77,779). It also appeared that compound 11a exhibits improved in vivo efficacy in the human colon CX-1 model when compared to either compound 8 or mitomycin C (MMC). Efficacious doses for 11a were found to be 2-fold lower than those for 8.