179748-03-9Relevant academic research and scientific papers
Derivatives of 5-amidine indole as inhibitors of thrombin catalytic activity
Iwanowicz, Edwin J.,Lau, Wan F.,Lin, James,Roberts, Daniel G. M.,Seiler, Steven M.
, p. 1339 - 1344 (2007/10/03)
Substituted 5-amidine indoles were constructed based upon a computational analysis of putative modes of binding to thrombin utilizing coordinates from the crystal structure of BMS-183,507-α-thrombin complex. These analogs display competitive kinetics for
