17975-48-3

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 5470-11-1 hydroxylamine hydrochloride 
• 105-45-3 acetoacetic acid methyl ester 
• 1517-96-0 3-methyl-5-isoxazolone 
• 5447-76-7 ethyl 3-oxobutanate oxime 

Downstream Products

• 35113-37-2 [(3-methyl-5-oxo-2,5-dihydro-isoxazol-4-yl)-p-tolyl-methyl]-phosphonic acid dimethyl ester 
• 4491-60-5 3''-methyl-3'-p-tolyl-dispiro[fluorene-9,1'-cyclopropane-2',4''-isoxazol]-5''-one 
• 128156-41-2 3-Methyl-4-(1-p-tolyl-ethyl)-4H-isoxazol-5-one 
• 128156-43-4 3-Methyl-4-(1-p-tolyl-ethyl)-2H-isoxazol-5-one 
• 136320-26-8 7-Methyl-2-p-tolyl-1,5-dioxa-6-aza-spiro[2.4]hept-6-en-4-one 
• 1569091-57-1 C₂₈H₂₃N₃O₃S 
• 128156-48-9 3,3'-Dimethyl-4,4'-bis-(4-methyl-benzyl)-4H,4'H-[4,4']biisoxazolyl-5,5'-dione 
• 128156-44-5 4-Bromo-3-methyl-4-(4-methyl-benzyl)-4H-isoxazol-5-one 
• 128156-46-7 4-Hydroxy-3-methyl-4-(4-methyl-benzyl)-4H-isoxazol-5-one 

Relevant academic research and scientific papers

Sonochemical synthesis of 3-methyl-4-arylmethylene isoxazole-5(4H)-ones by amine-modified montmorillonite nanoclay

Ultrasound irradiation was applied for the rapid and clean synthesis of 3-methyl-4-arylmethylene isoxazole-5(4H)-ones through condensation of hydroxylamine hydrochloride, ethyl acetoacetate and benzaldehyde derivatives. This methodology was effectively ca

Fruit Extract of Averrhoa bilimbi: A Green Neoteric Micellar Medium for Isoxazole and Biginelli-Like Synthesis

A transition metal/ligand/additive/promoter-free synthesis of 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones and the Biginelli-like synthesis is carried out in a natural acidic medium of Averrhoa bilimbi extract (ABE) with cleaner and facile approach smenti

A simple and efficient protocol for the synthesis of 3,4-disubstituted isoxazol-5(4h)-ones catalyzed by succinic acid using water as green reaction medium

A simple and efficient protocol has been established to the synthesis of 3,4-disubstituted isoxazol-5(4H)-ones via Knoevenagel condensation reaction. In this synthesis, succinic acid was used as an inexpensive catalyst and water as a green reaction medium

Facile and expedient synthesis of α,β-unsaturated isoxazol-5(4H)-ones under mild conditions

Abstract: It was found that nano-SiO2–H2SO4 was catalyzed by the three-component cyclocondensation of aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and β-ketoesters toward the synthesis of α,β-unsaturated?isoxazol-5(4H)-ones under green conditions. The reaction yielded the corresponding heterocycles at room temperature in relatively shorter reaction times. It merits mentioning that the mild conditions allow the synthesis of several α,β-unsaturated?isoxazol-5(4H)-ones using this method. In this study, some new derivatives of isoxazolones were also synthesized and characterized. It is efficient, clean, simple, safe, and ecologically friendly. This straightforward method is cost-effective and requires no preparation of reactants. The three-component annulation was performed without using energy sources, for example, heat, ultrasound wave, and microwave irradiation. Graphic abstract: [Figure not available: see fulltext.].

An improved protocol for the synthesis of 3,4-disubstituted isoxazol-5(4H)-ones through L-valine-mediated domino three-component strategy

Abstract: An expeditious, metal-free protocol has been demonstrated for the synthesis of isoxazolone derivatives using domino multi-component strategy. The envisaged methodology involves the L-valine promoted three-component cyclo-condensation reaction of

Cu/TCH-pr&at;SBA-15 nano-composite: A new organometallic catalyst for facile three-component synthesis of 4-arylidene-isoxazolidinones

A copper complex supported on SBA-15 nanoparticles (Cu/TCH-pr&at;SBA-15) was synthesized by the post-synthesis modification of nano-mesoporous silica with 3-chloropropyltriethoxysilane (CPTES) and thiocarbohydrazide (TCH) and subsequent metal-ligand coord

One-pot three-component synthesis of isoxazole using ZSM-5 as a heterogeneous catalyst

A mild and convenient route for the synthesis of isoxazole derivatives has been developed using ZSM-5 as a heterogeneous catalyst. The reaction was carried out under a solvent-free condition to afford the desired products in good yields. A variety of func

Green synthesis of 3,4-disubstituted isoxazol-5(4H)-ones using ZnO@Fe3O4 core–shell nanocatalyst in water

An effective and environmentally benign methodology for the synthesis of isoxazol-5(4H)-one derivatives has been developed using a ZnO@Fe3O4 core–shell nanocatalytic system. The one-pot, multicomponent reaction of an aromatic/heteroc

An expeditious synthesis of 3-methyl-4-arylmethylene-isoxazole-5(4H)-ones using aqueous extract of acacia concinna pods as a natural surfactant catalyst

An aqueous extract of Acacia concinna pods has been employed as a competent and effective natural surfactant type catalyst for the synthesis of 3-methyl-4-arylmethylene-isoxazole-5(4H)-one analogs through one-pot, three-component reaction of β-ketoester,

Synthesis and characterization of nanocrystalline hydroxyapatite and its catalytic behavior towards synthesis of 3,4-disubstituted isoxazole-5(4H)-ones in water

In the present work, the nanocrystalline particles of hydroxyapatite (HAp) using an easy alkoxide-based sol–gel technique including triethyl phosphate [PO (OC2H5)3] and Ca (NO3)2·4H2O as P and Ca precursors have been synthesized. The sample characterization was performed by X-ray diffraction, Fourier transform-infrared analysis, scanning electron microscopy, thermal analysis (thermogravimetric analysis/differential thermal analysis), and elemental analysis of energy-dispersive X-ray analysis. It is interesting that single phase of HAp was obtained at a low firing temperature of 500°C. Modified Scherrer equation as the Williamson?Hall method was applied for the measurement of crystallite size distributions and micro-strain of the sample. The determined crystallite size by complementary technique of transmission electron microscopy has good consistency with those obtained from the Scherrer formula. Moreover, we reported the one-pot synthesis of 3,4-disubstituted isoxazole-5(4H)-ones through the aqueous solution reaction of three components of ethyl acetoacetate, hydroxylamine hydrochloride and various aromatic aldehydes at room temperature. This protocol offers several advantages, including a simple work-up procedure, very short reaction times (under 25?min), in accordance with the principles of green chemistry, recyclability, excellent yields (87–98%) and environmentally friendly.