179798-73-3Relevant academic research and scientific papers
Synthesis and biological activities of camphor-based non-peptide growth hormone secretagogues
Nargund, Ravi P.,Barakat, Khaled H.,Cheng, Kang,Chan, Wanda W.-S,Butler, Bridget R.,Smith, Roy G.,Patchett, Arthur A.
, p. 1265 - 1270 (1996)
The synthesis and growth hormone (GH) releasing activities of a novel series of camphor-based non-peptide GH secretagogues is presented. Use of the (R)-nipecotic acid amino side-chain and N terminal derivatization of it with an (R)-(2-hydroxy)propyl group provided a potent secretagogue 18 (EC50 = 90 nM). An o-tolyl piperazine was identified as a good replacement for the spiroindanyl piperidine.
