Synthesis and biological activities of camphor-based non-peptide growth hormone secretagogues

DOI: 10.1016/0960-894X(96)00213-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1265 - 1270 (1996)

Update date:2022-08-03

Topics:

Authors:

Nargund, Ravi P.

Barakat, Khaled H.

Cheng, Kang

Chan, Wanda W.-S

Butler, Bridget R.

Smith, Roy G.

Patchett, Arthur A.

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Article abstract of DOI:10.1016/0960-894X(96)00213-2

The synthesis and growth hormone (GH) releasing activities of a novel series of camphor-based non-peptide GH secretagogues is presented. Use of the (R)-nipecotic acid amino side-chain and N terminal derivatization of it with an (R)-(2-hydroxy)propyl group provided a potent secretagogue 18 (EC₅₀ = 90 nM). An o-tolyl piperazine was identified as a good replacement for the spiroindanyl piperidine.

Full text of DOI:10.1016/0960-894X(96)00213-2

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