Bioorganic and Medicinal Chemistry Letters p. 1265 - 1270 (1996)
Update date:2022-08-03
Topics:
Nargund, Ravi P.
Barakat, Khaled H.
Cheng, Kang
Chan, Wanda W.-S
Butler, Bridget R.
Smith, Roy G.
Patchett, Arthur A.
The synthesis and growth hormone (GH) releasing activities of a novel series of camphor-based non-peptide GH secretagogues is presented. Use of the (R)-nipecotic acid amino side-chain and N terminal derivatization of it with an (R)-(2-hydroxy)propyl group provided a potent secretagogue 18 (EC50 = 90 nM). An o-tolyl piperazine was identified as a good replacement for the spiroindanyl piperidine.
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Doi:10.1039/dt9960002547
(1996)Doi:10.1002/anie.201806427
(2018)Doi:10.1055/s-2000-6399
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(1981)