Synthesis and biological activities of camphor-based non-peptide growth hormone secretagogues

Article abstract of DOI:10.1016/0960-894X(96)00213-2

The synthesis and growth hormone (GH) releasing activities of a novel series of camphor-based non-peptide GH secretagogues is presented. Use of the (R)-nipecotic acid amino side-chain and N terminal derivatization of it with an (R)-(2-hydroxy)propyl group provided a potent secretagogue 18 (EC₅₀ = 90 nM). An o-tolyl piperazine was identified as a good replacement for the spiroindanyl piperidine.