1798-03-4

Basic information

• Product Name: (2-ETHYL-PHENOXY)-ACETIC ACID
• Synonyms: Acetic acid,2-(2-ethylphenoxy)-;2-(2-ethylphenoxy)acetic acid
• CAS NO: 1798-03-4
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2
• Mol File: 1798-03-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 296.4°Cat760mmHg
• Flash Point: 115.2°C
• Appearance: /
• Density: 1.144g/cm³
• Vapor Pressure: 0.000649mmHg at 25°C
• CAS DataBase Reference: (2-ETHYL-PHENOXY)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2-ETHYL-PHENOXY)-ACETIC ACID(1798-03-4)
• EPA Substance Registry System: (2-ETHYL-PHENOXY)-ACETIC ACID(1798-03-4)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 1798-03-4(Hazardous Substances Data)

Usage

General Description

(2-ethyl-phenoxy)-acetic acid is a synthetic organic compound with the chemical formula C10H12O3. It is commonly used as a herbicide and plant growth regulator. The chemical works by disrupting the synthesis of plant hormones, leading to the inhibition of plant growth and eventually causing the death of the targeted plants. It is commonly used in agricultural and horticultural applications to control weeds and promote desirable plant growth. Additionally, it has also been used in research and development of new herbicide compounds. Overall, (2-ethyl-phenoxy)-acetic acid plays a key role in the management of vegetation and plant growth in various settings.

InChI:InChI=1/C10H12O3/c1-2-8-5-3-4-6-9(8)13-7-10(11)12/h3-6H,2,7H2,1H3,(H,11,12)/p-1

Upstream product

• 861143-60-4 (2-Ethyl-phenoxy)-acetic acid methyl ester 
• 90-00-6 o-Hydroxyethylbenzene 
• 100256-84-6 ethyl 2-(2-ethylphenoxy)acetate 
• 79-11-8 chloroacetic acid 

Downstream Products

• 90-00-6 o-Hydroxyethylbenzene 
• 124-38-9 carbon dioxide 
• 201230-82-2 carbon monoxide 
• 100256-84-6 ethyl 2-(2-ethylphenoxy)acetate 

Relevant articles and documents

Discovery of Novel UDP- N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa

This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor of Pseudomonas aeruginosa LpxA with no activity against Escherichia coli LpxA. The biochemical potency of the series was optimized through an X-ray crystallography-supported medicinal chemistry program, resulting in compounds with nanomolar activity against P. aeruginosa LpxA (best half-maximal inhibitory concentration (IC50) 20 μM and MIC > 128 μg/mL). The mode of action of analogues was confirmed through genetic analyses. As expected, compounds were active against multidrug-resistant isolates. Further optimization of pharmacokinetics is needed before efficacy studies in mouse infection models can be attempted. To our knowledge, this is the first reported LpxA inhibitor series with selective activity against P. aeruginosa.