1798014-18-2

Basic information

• Product Name: lopinavir
• CAS NO: 1798014-18-2
• Molecular Weight: 628.812
• Mol File: 1798014-18-2.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: lopinavir(CAS DataBase Reference)
• NIST Chemistry Reference: lopinavir(1798014-18-2)
• EPA Substance Registry System: lopinavir(1798014-18-2)

Safety Data

• Hazardous Substances Data: 1798014-18-2(Hazardous Substances Data)

Usage

Description

Lopinavir is a potent antiviral medication, specifically a selective HIV protease inhibitor, which plays a crucial role in the treatment of HIV and AIDS. It functions by inhibiting the activity of the HIV protease enzyme, thereby preventing the virus from replicating and spreading within the body. Lopinavir is often used in combination with other antiretroviral drugs to enhance its effectiveness and reduce the likelihood of drug resistance. Additionally, it has been identified as a COVID-19-related research product, indicating its potential application in the fight against the novel coronavirus.

Uses

Used in Pharmaceutical Industry:
Lopinavir is used as an antiviral agent for the treatment of HIV and AIDS. It targets the HIV protease enzyme, which is essential for the virus's replication process, thus inhibiting the virus's ability to multiply and spread within the host.
Used in COVID-19 Research:
Lopinavir is used as a research compound in the development of potential treatments for COVID-19. Its antiviral properties and mechanism of action make it a promising candidate for further investigation into its effectiveness against the novel coronavirus.

Upstream product

• 13335-71-2 2-(2,6-dimethylphenoxy)acetic acid 
• 192726-05-9 (2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(2-oxotetrahydropyrimidin-2-yl)-3-methylbutanoyl)amino-1,6-diphenylhexane 
• 20143-48-0 2,6-dimethylphenoxyacetyl chloride 
• 192800-77-4 2S-(1-tetrahydro-pyrimid-2-onyl)-3-methyl butanoyl chloride 
• 192725-49-8 (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane 
• 192725-85-2 (S)-3-Methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyric acid methyl ester 
• 192725-84-1 (S)-2-(3-Amino-propylamino)-3-methyl-butyric acid methyl ester 
• 6279-47-6 ethyl 2-(2,6-dimethylphenoxy)acetate 
• 576-26-1 2.6-dimethylphenol 
• 1026752-79-3 N-(3-aminopropyl)-N-(methoxycarbonyl)-L-valine 
• 192726-03-7 (S)-(-)-N-carboxymethyl-N(β)cyanoethyl valine 
• 51078-49-0 N-(2-cyanoethyl)-L-valine 
• 192726-06-0 (2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt 
• 224648-11-7 N-(2,6-dimethyl-phenyloxy acetyloxy)succinimide 

Relevant articles and documents

Synthesis of ABT-378, an HIV protease inhibitor candidate: Avoiding the use of carbodiimides in a difficult peptide coupling

An alternative to carbodiimide-mediated peptide coupling protocols has been developed for a carboxylic acid prone to decomposition by polymerization. This method, involving the in situ generation of an acyl imidazolide, has been applied to the preparation of a lead clinical HIV protease inhibitor candidate, ABT-378. The nature of the polymerization and optimization of the new reaction conditions are presented.

Synthesis and characterization of novel analogues of lopinavir

The present work describes the identification, origin, synthesis, characterization and control of four novel analogues of lopinavir viz. leucine analogue of lopinavir, isoleucine analogue of lopinavir, methyl analogue of lopinavir and dihydroxy analogue of lopinavir.

Novel method for preparing lopinavir

The invention relates to a novel method for preparing lopinavir (I), a condensation reaction of a compound shown in a formula (II) and a compound shown in a formula (III) is carried out at room temperature under mild condensation reaction conditions, and heating or cooling is not needed; the preparation method does not need special chemical reagents, the special chemical reagents are solvents andreagents commonly used in laboratories, the total yield is higher than 85%, preferably higher than 90%, in some embodiments, the yield reaches 96%, and the preparation method is especially suitable for industrial production.