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192725-49-8

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  • N-[(1S,2S,4S)-4-Amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-2-(2,6-dimethylphenoxy)acetamide Manufacturer/High quality/Best price/In stock

    Cas No: 192725-49-8

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  • BEST PRICE/N-[(1S,2S,4S)-4-Amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-2-(2,6-dimethylphenoxy)acetamide CAS NO.192725-49-8

    Cas No: 192725-49-8

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192725-49-8 Usage

Chemical Properties

Off-White Solid

Uses

(2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane (cas# 192725-49-8) is a compound useful in organic synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 192725-49-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,7,2 and 5 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 192725-49:
(8*1)+(7*9)+(6*2)+(5*7)+(4*2)+(3*5)+(2*4)+(1*9)=158
158 % 10 = 8
So 192725-49-8 is a valid CAS Registry Number.

192725-49-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane

1.2 Other means of identification

Product number -
Other names N-((2S,3S,5S)-5-Amino-3-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,6-dimethylphenoxy)acetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:192725-49-8 SDS

192725-49-8Relevant articles and documents

Novel crystal form of lopinavir and preparation method thereof

-

, (2021/05/26)

The invention discloses a novel crystal form of lopinavir and a preparation method thereof, belonging to the technical field of medicine crystal forms. According to the invention, lopinavir is prepared, and the novel crystal form of lopinavir is cultured; a real stereo structure of four chiral centers in a lopinavir molecule can be seen from an obtained single crystal structure; crystal data is recorded by a crystal database, namely CCDC 1969375, of the British Cambridge University for the first time; and compared with other detection methods reported at present, an X-ray single crystal diffraction method is the most direct and intuitive method for determining the absolute configuration and space structure of lopinavir.

Synthesis of novel heterocyclic sulfonamides as protease inhibitors of HIV-1

Ding, Yili,Smith, Kenneth L.,Vara Prasad, Chamakura V.N.S.,Wang, Bingyun

, p. 87 - 91 (2018/03/06)

Background: HIV-1 protease is a prime target for drug therapy due to its integral role in HIV viral replication. Several protease inhibitors such as lopinavir and tipranavir were shown to possess potent inhibitory activities against the HIV virus. Due to the high mutation rate of HIV, resistance remains a major problem in the treatment of this virus and design and synthesis of new protease inhibitors is an area of continued interest in new drug discovery research. Methods: Utilizing the key fragments of structures of both peptide-based and non-peptide-based protease inhibitors lopinavir and tipranavir, we explored designing some new compounds. Results: Six new protease inhibitors were designed and synthesized based on the key structural fragments in lopinavir and tipranavir. The designed new compounds contain heterocyclic groups such as thiophene, isoxazole, and imidazole groups, and the best compound exhibited 0.6 nm of the protease inhibitory activity. Conclusion: We have prepared some novel heterocyclic sulfonamides utilizing a key fragment based approach by recombining structural fragments of the potent protease inhibitors lopinavir and tipranavir. Some of these newly designed compounds showed good to excellent HIV-1 protease inhibitory activity, which indicated that this method would be useful for the discovery of new drug lead compounds that target HIV.

Novel Lopinavir analogues incorporating non-Aromatic P-1 side chains - Synthesis and structure-activity relationships

Sham, Hing L.,Zhao, Chen,Li, Leping,Betebenner, David A.,Saldivar, Ayda,Vasavanonda, Sudthida,Kempf, Dale J.,Plattner, Jacob J.,Norbeck, Daniel W.

, p. 3101 - 3103 (2007/10/03)

The HIV protease inhibitor Lopinavir has a pseudosymmetric core unit incorporating benzyl groups at both P-1, P-1′ positions. A series of analogues incorporating non-aromatic side chains at the P-1 position were synthesized and the structure-activity relationships explored.

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