179863-67-3

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 163190-47-4 (2S,4S)-N-tert-butoxycarbonyl-2-tert-butoxycarbonyl-4-hydroxymethylpyrrolidine 
• 163190-46-3 tert-Butyl (2S)-N-tert-butoxycarbonyl-4-methylideneprolinate 
• 84348-38-9 (S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid 

Downstream Products

• 163190-48-5 tert-Butyl (2S,4R)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylpyroglutamate 

Relevant academic research and scientific papers

Two independent syntheses of (2S,4S)- and (2S,4R)-[5,5-2H2]-5,5'-dihydroxyleucine

Two independent stereoselective syntheses have been used to prepare samples of (2S,4S)-[5,5-2H2]-5,5'-dihydroxyleucine (3b) and the (2S,4R)-diastereoisomer (3a). The first synthesis uses (2S)-pyroglutamic acid as starting material an

Synthesis of (2S,4S)- And (2S,4R)-5,5′-dihydroxy[5,5-2H2]leucine by two independent routes

In studies directed at discovering the absolute stereochemistry of the reaction catalysed by the enzyme glutamate γ-carboxylase, two independent stereoselective syntheses of (2S,4S)-5,5′-dihydroxy[5,5- 2H2]-leucine 4a and its (2S,4R)-diastereoisomer 4b have been developed. The first synthesis uses (2S)-pyroglutamic acid as starting material and provides (2S,4S)-5,5′-dihydroxy[5,5-2H2]leucine 4a, while the second starts with (2S,4R)-4-hydroxyproline and provides (2S,4R)-5,5′-dihydroxy[5,5-2H2]leucine 4b.