179863-72-0Relevant academic research and scientific papers
Synthesis of 1,2-dithiolane analogues of leucine for potential use in peptide chemistry.
Morera, Enrico,Pinnen, Francesco,Lucente, Gino
, p. 1139 - 1142 (2002)
[reaction: see text]1,2-Dithiolanes present several points of interest for both peptide and medicinal chemistry, yet no chiral alpha-amino acids containing this five-membered heterocyclic system are available. We report here the first synthesis of N- and C-protected derivative of (S)-2-amino-3-(1,2-dithiolan-4-yl)propionic acid (Adp) and its 1,3-dithiolic form.
