179897-92-8

Upstream product

• 452-08-4 2-bromo-4-fluoro-1-methoxybenzene 
• 320-75-2 2-bromo-4-fluoro-6-nitrophenol 
• 74-88-4 methyl iodide 

Downstream Products

• 179896-37-8 6-(5-Fluoro-2-methoxy-3-nitrophenyl)-1,2-dihydro-2,2,4-trimethylquinoline 
• 1176778-03-2 5'-fluoro-2'-methoxy-3'-nitro-biphenyl-3-carboxylic acid 
• 1260023-70-8 ethyl 4-[5-fluoro-2-(methyloxy)-3-nitrophenyl]butanoate 
• 1334607-89-4 ethyl 4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-5-fluoro-2-(methyloxy)phenyl]butanoate 
• 1334607-88-3 ethyl 4-[5-fluoro-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}-2-(methyloxy)phenyl]butanoate 
• 1334607-87-2 ethyl 4-[3-(2-chloro-5-pyrimidinyl)-5-fluoro-2-(methyloxy)phenyl]butanoate 
• 1334606-60-8 4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-(methyloxy)phenyl]butanoic acid 
• 1334606-57-3 4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-5-fluoro-2-(methyloxy)phenyl]butanoic acid 
• 1334606-54-0 4-[5-fluoro-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}-2-(methyloxy)phenyl]butanoic acid 
• 1260023-76-4 ethyl 4-[5-fluoro-2-(methyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoate 
• 1260023-74-2 ethyl 4-[3-bromo-5-fluoro-2-(methyloxy)phenyl]butanoate 
• 1260023-72-0 ethyl 4-[3-amino-5-fluoro-2-(methyloxy)phenyl]butanoate 

Relevant academic research and scientific papers

PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

Disclosed are pyrimidine derivatives for use as a sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.

PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

Disclosed are pyrimidine derivatives for use as sphingosine 1- phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.

5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS

5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.

BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description.