1799-18-4

Upstream product

• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 96755-16-7 1-(2-benzyloxy-5-fluorophenyl)-3-(6-benzodioxan-1,4-yl)propenone 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 96754-75-5 1-(2-benzyloxy-5-fluorophenyl)-3-(6-benzodioxan-1,4-yl)-2,3-epoxypropan-1-one 
• 96754-75-5 (2-Benzyloxy-5-fluoro-phenyl)-[(2S,3R)-3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-oxiranyl]-methanone 
• 307509-08-6 (2-benzyloxy-5-fluoro-phenyl)-[3-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-oxiranyl]-methanone 

Relevant academic research and scientific papers

MACROCYCLIC KINASE INHIBITOR

Disclosed is a macrocyclic kinase inhibitor, wherein the compound, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof is as shown in formula I. Experiments show that the new compound as shown in formula I disclosed in the present invention exhibits an excellent TRK inhibitory activity, has a significant inhibitory effect on TRKA-mutant cell growth, and exhibits an excellent inhibitory effect on in vivo tumor growth, thus providing a new choice for the clinical treatment of diseases associated with abnormal TRK activity.

3-cyano-2-aminopyridine derivative and preparation method and application thereof

The invention discloses a 3-cyano-2-aminopyridine derivative and a preparation method and an application thereof. The pyridine derivative is as shown in any one of 1) to 5): 1) a name is 2-amino-4-(4-bromophenyl)-6-(4-hydroxyphenyl)cyanopyridine; 2) 2-ami