1799-18-4

Basic information

• Product Name: 1-(2-benzyloxy-5-fluorophenyl)-ethanone
• Synonyms: 1-(2-benzyloxy-5-fluorophenyl)-ethanone
• CAS NO: 1799-18-4
• Molecular Weight: 244.265
• Mol File: 1799-18-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-benzyloxy-5-fluorophenyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-benzyloxy-5-fluorophenyl)-ethanone(1799-18-4)
• EPA Substance Registry System: 1-(2-benzyloxy-5-fluorophenyl)-ethanone(1799-18-4)

Safety Data

• Hazardous Substances Data: 1799-18-4(Hazardous Substances Data)

Upstream product

• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 96755-16-7 1-(2-benzyloxy-5-fluorophenyl)-3-(6-benzodioxan-1,4-yl)propenone 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 96754-75-5 1-(2-benzyloxy-5-fluorophenyl)-3-(6-benzodioxan-1,4-yl)-2,3-epoxypropan-1-one 
• 96754-75-5 (2-Benzyloxy-5-fluoro-phenyl)-[(2S,3R)-3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-oxiranyl]-methanone 
• 307509-08-6 (2-benzyloxy-5-fluoro-phenyl)-[3-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-oxiranyl]-methanone 

Relevant articles and documents

MACROCYCLIC KINASE INHIBITOR

Disclosed is a macrocyclic kinase inhibitor, wherein the compound, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof is as shown in formula I. Experiments show that the new compound as shown in formula I disclosed in the present invention exhibits an excellent TRK inhibitory activity, has a significant inhibitory effect on TRKA-mutant cell growth, and exhibits an excellent inhibitory effect on in vivo tumor growth, thus providing a new choice for the clinical treatment of diseases associated with abnormal TRK activity.