179915-15-2

Upstream product

• 762-72-1 allyl-trimethyl-silane 
• 109-00-2 3-HYDROXYPYRIDINE 
• 501-53-1 benzyl chloroformate 
• 179748-56-2 (+/-)-N-Carbobenzoxy-3-hydroxy-1,2,3,4-tetrahydropyridine 
• 330985-33-6 (S)-5-Acetoxy-2-methoxy-piperidine-1-carboxylic acid benzyl ester 
• 188660-16-4 (S)-N-Carbobenzoxy-3-hydroxy-1,2,3,4-tetrahydropyridine 

Downstream Products

• 179915-16-3 (2R,5S)-2-Allyl-5-hydroxy-piperidine-1-carboxylic acid benzyl ester 
• 403499-07-0 ((2R,5R)-1-Benzyl-5-hydroxymethyl-pyrrolidin-2-yl)-acetic acid tert-butyl ester 
• 403499-04-7 ((2R,5S)-1-Benzyl-5-hydroxy-piperidin-2-yl)-acetic acid tert-butyl ester 
• 403499-03-6 ((2R,5S)-5-Acetoxy-1-benzyl-piperidin-2-yl)-acetic acid tert-butyl ester 
• 403499-06-9 ((2R,5R)-5-Acetoxymethyl-1-benzyl-pyrrolidin-2-yl)-acetic acid tert-butyl ester 
• 403499-05-8 ((2R,5S)-1-Benzyl-5-methanesulfonyloxy-piperidin-2-yl)-acetic acid tert-butyl ester 
• 403499-02-5 (2R,5S)-5-Acetoxy-2-tert-butoxycarbonylmethyl-piperidine-1-carboxylic acid benzyl ester 
• 403499-09-2 [5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-2-yl]-acetic acid tert-butyl ester 
• 403499-08-1 [1-benzyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-2-yl]-acetic acid tert-butyl ester 
• 403499-10-5 2-tert-butoxycarbonylmethyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 330985-44-9 cis-5-Acetoxy-2-allyl-1-carbobenzoxypiperidine 
• 330985-36-9 ((2R,5S)-2-Allyl-5-hydroxy-piperidin-1-yl)-phenyl-methanone 
• 330985-37-0 (3S,6R)-6-Allyl-1-benzyl-piperidin-3-ol 

Relevant academic research and scientific papers

Diastereoselective synthesis of 3,5-trans-(+)-(3R,5R)-3-carbomethoxycarbapenam from 3-hydroxypyridine: Questioning the stereochemical assignment of the natural product

An enantio- and diastereoselective synthesis of the methyl ester of 3,5-trans-(3R,5R)-carbapenam-3-carboxylic acid from 3-hydroxypyridine via (2R,5S)-trans-5-acetoxy-2-allylpiperidine has been achieved by employing the piperidine-pyrrolidine ring-contract

Novel reduction of 3-hydroxypyridine and its use in the enantioselective synthesis of (+)-pseudoconhydrine and (+)-N-methylpseudoconhydrine

3-Hydroxypyridine is reduced with sodium borohydride in the presence of benzyl chloroformate to give 1-benzyloxycarbonyl-5-hydroxy-2-piperideine which is transformed into (+)-pseudoconhydrine and (+)-N-methylpseudoconhydrine in five steps involving a lipa