179950-22-2Relevant academic research and scientific papers
A practical synthesis of the milbemycin SB-201561
Andrews, Ian P.,Dorgan, Roderick J.J.,Harvey, Timothy,Hudner, Joseph F.,Hussain, Nigel,Lathbury, David C.,Lewis, Norman J.,Macaulay, Graham S.,Morgan, David O.,Stockman, Robert,White, Charles R.
, p. 4811 - 4814 (1996)
A 6-step synthesis of the potent anthelmintic SB-201561 is described. The key stage of the synthesis is a novel Beckmann type oxime fragmentation to give a lactone, followed by a 2-step reassembly of the spiroketal moiety.
