A practical synthesis of the milbemycin SB-201561

DOI: 10.1016/0040-4039(96)00943-4

Source and publish data:

Tetrahedron Letters p. 4811 - 4814 (1996)

Update date:2022-08-03

Topics:

Authors:

Andrews, Ian P.

Dorgan, Roderick J.J.

Harvey, Timothy

Hudner, Joseph F.

Hussain, Nigel

Lathbury, David C.

Lewis, Norman J.

Macaulay, Graham S.

Morgan, David O.

Stockman, Robert

White, Charles R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(96)00943-4

A 6-step synthesis of the potent anthelmintic SB-201561 is described. The key stage of the synthesis is a novel Beckmann type oxime fragmentation to give a lactone, followed by a 2-step reassembly of the spiroketal moiety.

Full text of DOI:10.1016/0040-4039(96)00943-4

Products guided by the article

Product name:(S)-Acetoxy-phenyl-acetic acid (S)-1-tert-butyl-3-oxo-butyl ester

Cas No:179950-22-2

R&D Labs maybe for 179950-22-2

Shantou Baokang Pharmaceutical Co., Ltd.

Contact:+86-754-88873487

Address:5/F B Block Huangshan Bldg Huangshan Rd Shantou
zhuzhou zhongle chemical co. ltd.

Contact:+86-0731 28228409

Address:Zhuzhou, Hunan, China
waho int'l company

Contact:+86-579-85206992

Address:No 451 chouzhou north road ,room 1106 int'l business center , yiwu ,china
Jinan Decheng Hemu Medical Technology Co.，Ltd.

Contact:+86-531-68650525

Address:NO.554 Zhengfeng Road High-new Technology Development Zone
Clearsynth Labs Limited

Contact:+91 - 22 - 26355700

Address:17, Lotus Business Park, Andheri West

Relevant to this article

A contribution to the asymmetric synthesis of 3-amine β-lactams: The diastereoselective [2+2] cycloaddition reaction of chiral aminoketene equivalents with enolizable aldehyde-derived/mines

Doi:10.1002/chem.19970030909
(1997)
α-Sulfenyl-Directed Ring-Opening Reactions of Epoxides. 1. Highly Regio- and Stereoselective Reaction with Organo-Aluminum Reagents and Application to the Synthesis of an Aggregation Pheromone

Doi:10.1246/bcsj.69.2095
(1996)
A new one pot method for the conversion of aldehydes into nitriles using hydroxyamine and phthalic anhydride

Doi:10.1016/S0040-4039(98)00654-6
(1998)
β-agostic silylamido and silyl-hydrido compounds of molybdenum and tungsten

Doi:10.1021/ic900591e
(2009)
1,2,3-benzotriazinone 1-oxides

Doi:10.1039/P19890000543
(1989)
β-ionone reactions with the nitrate radical: Rate constant and gas-phase products

Doi:10.1002/kin.20438
(2009)

Article Doi