A practical synthesis of the milbemycin SB-201561

DOI: 10.1016/0040-4039(96)00943-4

Source and publish data:

Tetrahedron Letters p. 4811 - 4814 (1996)

Update date:2022-08-03

Topics:

Authors:

Andrews, Ian P.

Dorgan, Roderick J.J.

Harvey, Timothy

Hudner, Joseph F.

Hussain, Nigel

Lathbury, David C.

Lewis, Norman J.

Macaulay, Graham S.

Morgan, David O.

Stockman, Robert

White, Charles R.

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Article abstract of DOI:10.1016/0040-4039(96)00943-4

A 6-step synthesis of the potent anthelmintic SB-201561 is described. The key stage of the synthesis is a novel Beckmann type oxime fragmentation to give a lactone, followed by a 2-step reassembly of the spiroketal moiety.

Full text of DOI:10.1016/0040-4039(96)00943-4

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Product name:(S)-Acetoxy-phenyl-acetic acid (S)-1-tert-butyl-3-oxo-butyl ester

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