Tetrahedron Letters p. 4811 - 4814 (1996)
Update date:2022-08-03
Topics:
Andrews, Ian P.
Dorgan, Roderick J.J.
Harvey, Timothy
Hudner, Joseph F.
Hussain, Nigel
Lathbury, David C.
Lewis, Norman J.
Macaulay, Graham S.
Morgan, David O.
Stockman, Robert
White, Charles R.
A 6-step synthesis of the potent anthelmintic SB-201561 is described. The key stage of the synthesis is a novel Beckmann type oxime fragmentation to give a lactone, followed by a 2-step reassembly of the spiroketal moiety.
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