180003-04-7Relevant articles and documents
Synthesis and structure-activity relationship of potent bicyclic lactam thrombin inhibitors
Bachand, Benoit,DiMaio, John,Siddiqui, M. Arshad
, p. 913 - 918 (1999)
A simple and versatile method for preparation of (D)-Phe-Pro peptidomimetic bicyclic thiazolidine lactams is presented. These bicyclic lactams have chemical diversity α to the lactam carbonyl and, when linked to electrophilic arginines, provide potent thrombin inhibitors.