18004-62-1

Basic information

• Product Name: C-Quinolin-2-yl-methylamine dihydrochloride
• Synonyms: C-Quinolin-2-yl-methylamine dihydrochloride;2-QuinolineMethanaMine, dihydrochloride;Quinolin-2-ylmethanamine dihydrochloride
• CAS NO: 18004-62-1
• Molecular Formula: C₁₀H₁₀N₂*2ClH
• Molecular Weight: 231.12168
• Mol File: 18004-62-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 355.6 °C at 760 mmHg
• Flash Point: 168.8 °C
• Appearance: /
• CAS DataBase Reference: C-Quinolin-2-yl-methylamine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: C-Quinolin-2-yl-methylamine dihydrochloride(18004-62-1)
• EPA Substance Registry System: C-Quinolin-2-yl-methylamine dihydrochloride(18004-62-1)

Safety Data

• Hazardous Substances Data: 18004-62-1(Hazardous Substances Data)

Usage

General Description

C-Quinolin-2-yl-methylamine dihydrochloride is a chemical compound with potential pharmaceutical applications. It is a quinoline derivative with a methylamine substituent, and is typically found in the form of a dihydrochloride salt. C-Quinolin-2-yl-methylamine dihydrochloride has been studied for its potential as an anti-inflammatory and antiviral agent. It may also have potential as a treatment for neurodegenerative diseases due to its ability to inhibit the production of amyloid-beta peptides, which are associated with Alzheimer's disease. C-Quinolin-2-yl-methylamine dihydrochloride shows promise as a versatile compound with potential therapeutic applications in various disease states.

Upstream product

• 5470-96-2 quinoline 2-carbaldehyde 
• 5632-15-5 quinolin-2-ylmethylbromide 
• 1780-17-2 quinolin-2-ylmethanol 
• 19575-07-6 quinoline-2-carboxylic acid methyl ester 
• 1393887-11-0 N,N-di-Boc-quinolin-2-ylmethanamine 
• 76278-23-4 2-Phenyl-4-(2-quinolyl)-2-oxazolin-5-one 

Downstream Products

• 5760-20-3 2-aminomethylquinoline 
• 93323-37-6 N-(quinolin-2-ylmethyl)benzamide 
• 67868-28-4 N-((1,2,3,4-tetrahydroquinolin-2-yl)methyl)benzamide 
• 440099-02-5 2-[1-(3,4-Dimethoxy-benzyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl]-2-phenyl-N-quinolin-2-ylmethyl-acetamide 

Relevant articles and documents

Fabrication of ω-Transaminase@Metal-Organic Framework Biocomposites for Efficiently Synthesizing Benzylamines and Pyridylmethylamines

In this study, ten ω-transaminases (ω-TAs) have been investigated to efficiently catalyze the synthesis of twenty-four functionalized benzylamines and pyridylmethylamines. We optimized the reactions, screened suitable amino donors and compared ω-transaminases activities for all aromatic aldehyde substrates. Under the optimized conditions, eighteen aromatic amines have been obtained with 60.4%–96.6% conversions and isolated only via simple extraction and recrystallization with 18.5%–81% yields on a preparative scale. Furthermore, we first immobilized the Bm-STA onto the MOFs via the physical adsorption to overcome the limitation of free enzyme and improve their industrial applications. The obtained Bm-STA/UiO-66-NH2 composites exhibited not only high enzymes loading (80.4 mg g?1) and enzyme activity recovery (95.8%), but also the better reusability, storage stability, pH stability and the tolerance to acetone and DMF.

Studies of Tertiary Amine Oxides. LXVIII. (1). Reactions of Aromatic N-Oxides with 2-Substituted 2-Oxazolin-5-ones in the Presence of Acetic Anhydride

Quinoline 1-oxides 1a-f readily react with 2-phenyl- and 2-methyl-2-oxazolin-5-ones, 2a and 2b, in the presence of acetic anhydride to afford 2-substituted 4-(2-quinolyl)-2-oxazolin-5-ones 3a-h in good yields.Hydrolysis of 3a-f with 10percent hydrochloric acid under refluxing conditions gives the corresponding 2-aminomethylquinoline dihydrochlorides 5a-e or monohydrochloride 5f also in good yields.Similar results are obtained from reactions of isoquinoline 2-oxide 9 with 2a,b under the same conditions.