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Usage

Uses

Used in Pharmaceutical Industry:
C-Quinolin-2-yl-methylamine dihydrochloride is used as an anti-inflammatory agent for its potential to reduce inflammation, which is a common factor in many diseases and conditions.
Used in Antiviral Applications:
In the field of virology, C-Quinolin-2-yl-methylamine dihydrochloride is utilized as an antiviral agent, potentially inhibiting the replication and spread of viruses, thereby offering a therapeutic approach to viral infections.
Used in Neurodegenerative Disease Treatment:
C-Quinolin-2-yl-methylamine dihydrochloride is employed as a treatment for neurodegenerative diseases, particularly Alzheimer's, due to its ability to inhibit the production of amyloid-beta peptides, which are implicated in the pathogenesis of the disease.
Used in Research and Development:
In the scientific community, C-Quinolin-2-yl-methylamine dihydrochloride serves as a versatile compound in research for exploring its potential in various disease states, contributing to the advancement of medical knowledge and the development of new therapeutic strategies.

Upstream product

• 76278-23-4 2-Phenyl-4-(2-quinolyl)-2-oxazolin-5-one 
• 1393887-11-0 N,N-di-Boc-quinolin-2-ylmethanamine 
• 19575-07-6 quinoline-2-carboxylic acid methyl ester 
• 1780-17-2 quinolin-2-ylmethanol 
• 5632-15-5 quinolin-2-ylmethylbromide 
• 5470-96-2 quinoline 2-carbaldehyde 

Downstream Products

• 5760-20-3 2-aminomethylquinoline 
• 93323-37-6 N-(quinolin-2-ylmethyl)benzamide 
• 67868-28-4 N-((1,2,3,4-tetrahydroquinolin-2-yl)methyl)benzamide 
• 440099-02-5 2-[1-(3,4-Dimethoxy-benzyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl]-2-phenyl-N-quinolin-2-ylmethyl-acetamide 

Relevant academic research and scientific papers

Fabrication of ω-Transaminase@Metal-Organic Framework Biocomposites for Efficiently Synthesizing Benzylamines and Pyridylmethylamines

In this study, ten ω-transaminases (ω-TAs) have been investigated to efficiently catalyze the synthesis of twenty-four functionalized benzylamines and pyridylmethylamines. We optimized the reactions, screened suitable amino donors and compared ω-transaminases activities for all aromatic aldehyde substrates. Under the optimized conditions, eighteen aromatic amines have been obtained with 60.4%–96.6% conversions and isolated only via simple extraction and recrystallization with 18.5%–81% yields on a preparative scale. Furthermore, we first immobilized the Bm-STA onto the MOFs via the physical adsorption to overcome the limitation of free enzyme and improve their industrial applications. The obtained Bm-STA/UiO-66-NH2 composites exhibited not only high enzymes loading (80.4 mg g?1) and enzyme activity recovery (95.8%), but also the better reusability, storage stability, pH stability and the tolerance to acetone and DMF.

Synthesis of new chiral 2-functionalized-1,2,3,4-tetrahydroquinoline derivatives via asymmetric hydrogenation of substituted quinolines

The asymmetric hydrogenation of a series of quinolines substituted by a variety of functionalized groups linked to the C2 carbon atom is providing access to optically enriched 2-functionalized 1,2,3,4-tetrahydroquinolines in the presence of in situ generated catalysts from [Ir(cod)Cl]2, a bisphosphine, and iodine. The enantioselectivity levels were as high as 96% ee.

Studies of Tertiary Amine Oxides. LXVIII. (1). Reactions of Aromatic N-Oxides with 2-Substituted 2-Oxazolin-5-ones in the Presence of Acetic Anhydride

Quinoline 1-oxides 1a-f readily react with 2-phenyl- and 2-methyl-2-oxazolin-5-ones, 2a and 2b, in the presence of acetic anhydride to afford 2-substituted 4-(2-quinolyl)-2-oxazolin-5-ones 3a-h in good yields.Hydrolysis of 3a-f with 10percent hydrochloric acid under refluxing conditions gives the corresponding 2-aminomethylquinoline dihydrochlorides 5a-e or monohydrochloride 5f also in good yields.Similar results are obtained from reactions of isoquinoline 2-oxide 9 with 2a,b under the same conditions.