5632-15-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromomethylquinoline is used as a building block for the synthesis of various pharmaceuticals due to its diverse range of biological activities, including antibacterial, antifungal, and antimalarial properties. Its versatile chemical structure allows for the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Bromomethylquinoline is utilized as a precursor in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in Organic Synthesis:
2-Bromomethylquinoline serves as a reagent in organic synthesis, facilitating the creation of a variety of chemical compounds for research and industrial applications.
Used in Specialty Chemicals Production:
As a precursor, 2-Bromomethylquinoline is involved in the production of specialty chemicals, which are used in various industries, including coatings, dyes, and fragrances.
Used in Cancer Treatment Research:
2-Bromomethylquinoline is studied for its potential role in treating cancer, with ongoing research exploring its therapeutic effects and mechanisms of action.
Used in Inflammation Treatment Research:
2-Bromomethylquinoline is also being investigated for its potential in treating inflammation and other diseases, highlighting its broad scope of applications in the medical field.

InChI:InChI=1/C15H20N4O2S/c1-11-13(17-15(22)16-9-10-21-3)14(20)19(18(11)2)12-7-5-4-6-8-12/h4-8H,9-10H2,1-3H3,(H2,16,17,22)

Upstream product

• 91-63-4 2-methylquinoline 
• 100-46-9 benzylamine 

Downstream Products

• 10065-72-2 L-Alanine methyl ester 
• 143004-77-7 (R)-α-(2-Chinolylmethyl)alanin-methylester 
• 71785-65-4 (S)-α-(2-Chinolylmethyl)alanin-methylester 
• 142820-23-3 4-t-butylcyclohexyl 2-quinolinyl-methyl ether 
• 136694-18-3 methyl 3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropionate 
• 583033-33-4 2-[(2R,3R,4S,5R)-2-(4-Methoxy-benzyloxymethyl)-4,5,6-tris-methoxymethoxy-tetrahydro-pyran-3-yloxymethyl]-quinoline 
• 583033-26-5 2-[(2R,3R,4S,5R)-3-(4-Methoxy-benzyloxy)-4,5,6-tris-methoxymethoxy-tetrahydro-pyran-2-ylmethoxymethyl]-quinoline 
• 39111-94-9 3-(quinoline-2-yl)propanoic acid 
• 1189240-24-1 (+)-2-[(2R,5R)-(2,5-diphenylpyrrolidin-1-yl)methyl]quinoline 
• 1337912-92-1 2-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline 
• 1780-19-4 1,2,3,4-tetrahydro-2-methylquinoline 

Relevant academic research and scientific papers

Direct Access to Halogenated Fused Imidazo[1,5-a]N-heteroaromatics through Copper-Promoted Double Oxidative C–H Amination and Halogenation

An aerobic copper-promoted double oxidative C–H amination and halogenation tandem reaction of 2-methylazarenes with aliphatic amines or amino acids has been developed. The reaction uses copper salts as catalysts as well as halogen sources, and molecular oxygen as the sole oxidant. This protocol is operationally simple, and gives direct access to functionalised fused imidazoles in a one-pot operation with good functional-group tolerance. The synthetic utility of the products has been tested in a Suzuki cross-coupling reaction, which proceeded in good yield.

Aerobic Copper-Catalyzed Halocyclization of Methyl N-Heteroaromatics with Aliphatic Amines: Access to Functionalized Imidazo-Fused N-Heterocycles

A new aerobic copper-catalyzed halocyclization reaction of methyl N-heteroaromatics and aliphatic amines has been developed, which enables straightforward access to functionalized imidazo-fused N-heterocycles with the merits of good functional tolerance, use of easily available copper salts as the catalysts, lithium halides as the halogen sources, and O2 as a sole oxidant. Due to the reaction features' selective introduction of halogen functionalities to the newly formed imidazo ring, further extensions of the developed chemistry toward synthetic diversity, including effective access to functional materials, are easily envisioned.

Synthesis of quinoline coupled [1,2,3]-triazoles as a promising class of anti-tuberculosis agents

A series of quinoline coupled 1,2,3-triazoles compounds have been synthesized by 'click chemistry' from azidomethyl quinoline with different alkynes. The efficiency and fidelity of the Cu(I)-catalyzed azide-alkyne reaction are substantiated by good yields and exclusive formation of the expected 1,4-disubstituted triazole product. All the synthesized compounds were screened for anti-tubercular activity against Mycobacterium tuberculosis H37Rv by luciferase reporter phage (LRP) assay. Quinoline coupled triazole sugar hybrid, 20 is the most potent compound in the series with 76.41% and 78.37% reduction calculated based on percentage reduction in Relative Light Units at 5 and 25 μg/mL, respectively.