5632-15-5Relevant articles and documents
Direct Access to Halogenated Fused Imidazo[1,5-a]N-heteroaromatics through Copper-Promoted Double Oxidative C–H Amination and Halogenation
Sandeep, Mummadi,Swati Dushyant, Patil,Sravani, Boda,Rajender Reddy, Kallu
, p. 3036 - 3047 (2018/06/27)
An aerobic copper-promoted double oxidative C–H amination and halogenation tandem reaction of 2-methylazarenes with aliphatic amines or amino acids has been developed. The reaction uses copper salts as catalysts as well as halogen sources, and molecular oxygen as the sole oxidant. This protocol is operationally simple, and gives direct access to functionalised fused imidazoles in a one-pot operation with good functional-group tolerance. The synthetic utility of the products has been tested in a Suzuki cross-coupling reaction, which proceeded in good yield.
Synthesis of quinoline coupled [1,2,3]-triazoles as a promising class of anti-tuberculosis agents
Karthik Kumar,Prabu Seenivasan,Kumar, Vanaja,Mohan Das
body text, p. 2084 - 2090 (2011/11/06)
A series of quinoline coupled 1,2,3-triazoles compounds have been synthesized by 'click chemistry' from azidomethyl quinoline with different alkynes. The efficiency and fidelity of the Cu(I)-catalyzed azide-alkyne reaction are substantiated by good yields and exclusive formation of the expected 1,4-disubstituted triazole product. All the synthesized compounds were screened for anti-tubercular activity against Mycobacterium tuberculosis H37Rv by luciferase reporter phage (LRP) assay. Quinoline coupled triazole sugar hybrid, 20 is the most potent compound in the series with 76.41% and 78.37% reduction calculated based on percentage reduction in Relative Light Units at 5 and 25 μg/mL, respectively.
