180079-93-0

Basic information

• Product Name: Carbamic acid, [2-(3-nitrophenyl)ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 180079-93-0
• Molecular Formula: C13H18N2O4
• Mol File: 180079-93-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-(3-nitrophenyl)ethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-(3-nitrophenyl)ethyl]-, 1,1-dimethylethyl ester(180079-93-0)
• EPA Substance Registry System: Carbamic acid, [2-(3-nitrophenyl)ethyl]-, 1,1-dimethylethyl ester(180079-93-0)

Safety Data

• Hazardous Substances Data: 180079-93-0(Hazardous Substances Data)

Upstream product

• 619-23-8 3-Nitrobenzyl chloride 
• 621-50-1 (3-nitrophenyl)acetonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 83304-13-6 2-(3-nitrophenyl)ethylamine 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

BICYCLOANILINE DERIVATIVE

The invention relates to a compound of a general formula (I): wherein A1 and A2 each mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; R1 means a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; R2 means an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of =NH or =O, etc. Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.

Integrin expression inhibitors

The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. In the formula, B means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated; K means a single bond, —CH═CH— or —(CR4bR5b)mb— (wherein R4b and R5b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group; and mb means an integer of 1 or 2); R1 means hydrogen atom or a C1-C6 alkyl group; Z means a single bond or —CO—NH—; and R means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.