83304-13-6

Basic information

• Product Name: 3-NITROPHENYLETHYLAMINE
• Synonyms: RARECHEM AL BW 0475;3-NITRO-PHENETHYLAMINE;3-NITROPHENYLETHYLAMINE;2-(3-NITROPHENYL)ETHANAMINE;2-(3-nitrophenyl)ethan-1-aMine;BenzeneethanaMine,3-nitro-
• CAS NO: 83304-13-6
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• EINECS: 200-258-5
• Product Categories: Miscellaneous
• Mol File: 83304-13-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 211-215 °C
• Boiling Point: 304.024 °C at 760 mmHg
• Flash Point: 137.669 °C
• Appearance: /
• Density: 1.206 g/cm³
• Vapor Pressure: 0.00242mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.41±0.10(Predicted)
• CAS DataBase Reference: 3-NITROPHENYLETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITROPHENYLETHYLAMINE(83304-13-6)
• EPA Substance Registry System: 3-NITROPHENYLETHYLAMINE(83304-13-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 83304-13-6(Hazardous Substances Data)

Usage

Uses

2-(3-Nitrophenyl)ethanamine can be used as TRPM8 inhibitors to treat diseases or conditions caused by hyperexcitability of afferent nerves.

InChI:InChI=1/C8H10N2O2/c1-2-9-7-4-3-5-8(6-7)10(11)12/h3-6,9H,2H2,1H3

Upstream product

• 7697-37-2 nitric acid 
• 64-04-0 phenethylamine 
• 223741-86-4 1-(2-azidoethyl)-3-nitrobenzene 
• 75-09-2 dichloromethane 
• 603-35-0 triphenylphosphine 
• 22888-56-8 3-nitrophenylalanine 
• 555-68-0 m-Nitrocinnamic Acid 
• 882-26-8 (E)-1-nitro-3-(2-nitrovinyl)benzene 
• 99-61-6 3-nitro-benzaldehyde 
• 1403029-71-9 2-3-nitrophenylethylcarbamic acid methyl ester 
• 619-23-8 3-Nitrobenzyl chloride 
• 1664-57-9 3-(3-nitrophenyl)propanoic acid 
• 621-50-1 (3-nitrophenyl)acetonitrile 
• 134306-94-8 3-(3-nitrophenyl)propanamide 

Downstream Products

• 121-92-6 3-nitrobenzoic acid 
• 180079-93-0 N-(3-nitrophenylmethyl)methylcarbamic acid t-butyl ester 
• 1185466-27-6 C₃₂H₃₉N₃O₅Si 
• 1185463-88-0 N-(2,6-dichlorobenzyl)-N'-[3-(2-{[(2R,S)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}ethyl)phenyl]urea 
• 1185463-82-4 N-(diphenylmethyl)-N'-[3-(2-{[(2R,S)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}ethyl)phenyl]urea 
• 1185463-90-4 N-biphenyl-2-yl-N'-[3-(2-{[(2RS)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}ethyl)phenyl]urea 
• 1185464-03-2 N-[3-(2-{[(2R,S)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]-amino}ethyl)phenyl]-N'-(3-phenoxyphenyl)urea 
• 1185464-34-9 N-(4-tert-butylbenzyl)-N'-[3-(2-{[(2R,S)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro-quinolin-5-yl)ethyl]amino}ethyl)phenyl]urea 
• 1185463-83-5 N-[3-(2-{[(2R,S)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]-amino}ethyl)phenyl]-N'-phenylurea 
• 1185465-25-1 tert-butyl [2-(3-isocyanatophenyl)ethyl]carbamate 
• 1185465-48-8 tert-butyl (2-{3-[(anilinocarbonyl)amino]phenyl}ethyl)carbamate 
• 1185465-18-2 tert-butyl [2-(3-{[(benzylamino)carbonyl]amino}phenyl)ethyl]-carbamate 
• 1185465-29-5 tert-butyl {2-[3-({[(2-phenylethyl)amino]carbonyl}amino)phenyl]-ethyl}carbamate 
• 1185465-33-1 tert-butyl {2-[3-({[(3-phenylpropyl)amino]carbonyl}amino)phenyl]-ethyl}carbamate 

Relevant articles and documents

Bi-enzymatic Conversion of Cinnamic Acids to 2-Arylethylamines

The conversion of carboxylic acids, such as acrylic acids, to amines is a transformation that remains challenging in synthetic organic chemistry. Despite the ubiquity of similar moieties in natural metabolic pathways, biocatalytic routes seem to have been overlooked for this purpose. Herein we present the conception and optimisation of a two-enzyme system, allowing the synthesis of β-phenylethylamine derivatives from readily-available ring-substituted cinnamic acids. After characterisation of both parts of the reaction in a two-step approach, a set of conditions allowing the one-pot biotransformation was optimised. This combination of a reversible deaminating and irreversible decarboxylating enzyme, both specific for the amino acid intermediate in tandem, represents a general method by which new strategies for the conversion of carboxylic acids to amines could be designed.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids

A one-pot synthesis of tetrahydroisoquinoline alkaloids in a phosphate buffer has been achieved, and a reaction mechanism proposed. The utilisation of mild reaction conditions readily afforded a range of isoquinolines, including norcoclaurine.